西格列汀与二甲双胍对初诊为2型糖尿病患者疗效及血清炎性因子影响.docVIP

西格列汀与二甲双胍对初诊为2型糖尿病患者疗效及血清炎性因子影响 　　[摘要] 目的 研究二甲双胍联合西格列汀治疗初发2型糖尿病的临床治疗效果和患者体内的血清炎性因子的具体变化波动。 方法 将2013年12月―2015年12月收治的100例诊断为初发2型糖尿病患者，按照随机分配的原则，分为观察组和对照组，每组50例。两组在治疗的基础上都进行常规的低糖饮食控制和基本的运动辅助治疗， 观察组使用二甲双胍和磷酸西格列汀片联合治疗，对照组给予患者盐酸二甲双胍片进行治疗。 结果 观察组和对照组的治疗结果显示，两组治疗之后3个月空腹血糖和2 h血糖以及糖化的血红蛋白的含量均显著下降，与对照组相比，观察组治疗3个月之后空腹血糖、2 h之后的血糖、糖化血红蛋白则均显著降低，差异有统计学意义（P0.01）。观察组消化系统的不良反应发生率显著低于对照组（P0.05），两组患者都没有出现血糖过低及肝、肾功能损坏的变化。结论 二甲双胍联合西格列汀治疗初发2型糖尿病临床效果优异，能显著保持患者的血糖维持在正常范围，值得在临床上推广和应用。 　　[关键词] 西格列汀与二甲双胍；初诊为2型糖尿病患者；疗效 　　[中图分类号] R587.2 [文献标识码] A [文章编号] 1672-4062（2016）12（b）-0003-02 　　[Abstract] Objective To study the clinical effect of metformin combined with pioglitazone in the treatment of patients with type 2 diabetes mellitus and the changes of serum inflammatory factors in patients. Methods From December 2013 to December 2015， 2 cases of type 100 diabetes patients diagnosed as primary type diabetes were divided into observation group and control group according to the principle of random distribution， 50 cases in each group. The treatment in the 2 groups on the basis of routine diet control of low sugar and basic motion adjuvant therapy， the observation group used metformin and Sitagliptin Phosphate Tablets combined treatment， the control group was given treatment with Metformin Hydrochloride Tablets. Results The treatment group and control group. The results show that the two groups after 3 months of treatment and two hours of fasting blood glucose and glycosylated hemoglobin content were significantly decreased， compared with the control group， the observation group after treatment 3 months after two hours of fasting blood glucose， blood glucose， glycosylated hemoglobin decreased significantly， the difference have a significant statistical difference（P0.01）. The incidence of adverse reactions in the observation group was significantly lower than that in the control group（P0.05）， and there was no change in the two groups of patients with low blood sugar and liver and renal function dam