痹痛宁凝胶膏剂的药学研究-药剂学专业论文.docxVIP

PAGE PAGE IV coating thickness of 2.5mm, applied to the non-woven fabric, 60 ℃ drying, cut into 7cm × 10cm size. In the research of preparation’s quality criteria,TLC was used to identify all the herbs in the preseription. HPLC was used to determine content of Gentiopicroside which is the active component of Gentianae macrophyllae Radix, and systematic methodological study was established. The experimental results met the requirements, so they were brought into the text. According to the result of there batches of samples, individual provision stardards was made with the content of Gentiopicroside. In the stability research, accelerated test and long-term test for six month of there batches of samples had been conducted. The results showed that no change in appearance and performance, TLC identification of a positive reaction, the amount of gypsum, forming, adhesion, and content are qualified. Key words: Bi Tong-ning; Cataplasm; preparation teconology; quality stardard; preliminary srabilit. 目录 中文摘要 1 ABSTRACT II HYPERLINK \l _bookmark0 引言 1 HYPERLINK \l _bookmark1 1.立题依据 1 HYPERLINK \l _bookmark2 2.类风湿关节炎的研究现状 3 HYPERLINK \l _bookmark3 3.痹痛宁方分析 5 HYPERLINK \l _bookmark4 4.课题研究思路 7 HYPERLINK \l _bookmark5 正文 9 HYPERLINK \l _bookmark6 第一章 提取工艺研究 9 HYPERLINK \l _bookmark7 第一节 提取工艺路线的筛选 9 HYPERLINK \l _bookmark8 第二节 提取工艺参数的优化 13 HYPERLINK \l _bookmark9 第三节 本章小结和讨论 21 HYPERLINK \l _bookmark10 第二章 制剂成型工艺研究 23 HYPERLINK \l _bookmark11 第一节 基质处方筛选 23 HYPERLINK \l _bookmark12 第二节 Box-Behken 设计优化处方研究 27 HYPERLINK \l _bookmark13 第三节 透皮促渗剂的筛选 32 HYPERLINK \l _bookmark14 第四节 制剂成型工艺处方的确立及工艺放大研究 42 HYPERLINK \l _bookmark15 第五节 本章小结和讨论 46 HYPERLINK \l _bookmark16 第三章 质量标准研究 47 HYPERLINK \l _bookmark17 第一节 质量标准（正文） 47 HYPERLINK \l _bookmark18 第二节 药品成品的质量标准起草说明 50 HYPERLINK \l _bookmark19 第三节 本章小结和讨论 64 HYPERLINK \l _bookmark20 第四章 初步稳定性研究 65 HYPERLINK \l _bookmark21 第一节 初步稳定性研究 65 HYPERLINK \l _bookmark22 第二节 本章小结和讨论 68 HYPERLINK \l _bookmark23 总结