正己烷英文.ppt

* * n-hexane, C6H14 * * 无尘车间的怪病 2010.2.21 * * Physical and chemical properties At room temperature under a slight smell of liquid, volatile, almost insoluble in water, soluble in chloroform, ether, ethanol. * * 1) Glues, paints and adhesives, now use benzene glue containing a higher concentration of n-hexane; 2) Use for the extraction of vegetable oils and synthetic rubber; 3)Manufacturing low temperature thermometer and Chemicals. opportunities for contact * * Toxicology（1） 1 Pathways In vapor form into the body through the respiratory tract, can also be absorbed through the gastrointestinal tract; less absorbed through the skin. (2) Distribution Organ fat content, mainly in the blood, nervous system, kidneys, spleen, etc. * * 3.Metabolism?????? Mainly in the liver is oxidized metabolites in the urine (may reflect the level of exposure).?????? Hexane by metabolism in the body of other chemicals, can slow down metabolism of toluene; acetone, methyl ethyl ketone, isopropyl alcohol can accelerate the metabolism. * * 4.Toxic mechanism Now that its major metabolite 2,5 - dione and neurofilament protein covalently bound to the lysine to form 2,5 - dimethyl-pyrrole adduct, causing neurofilament accumulation, leading to axonal transport disorders and nerve fiber degeneration - neurotoxic * * Clinical manifestation 1. acute poisoning: Neurological symptoms, dizziness, headache, chest tightness; Eyes and upper respiratory tract irritation; Symptoms of anesthesia; Oral intake can cause nausea, vomiting, bronchial and gastrointestinal irritation, severe cases of CNS or respiratory system depression. * * 2.Chronic poisoning Nervous system: peripheral neuropathy caused by multiple (pain, touch, movement), which is characterized by insidious onset and slow progress. Pain, decreased general was tactile gloves, socks type distributions. Cardiovascular: arrhythmia. Reproductive system: spermatogenesis process is affected by interference Immune system: serum immu