递增负荷运动对大鼠肾上腺甲状腺轴激素影响.docVIP

递增负荷运动对大鼠肾上腺甲状腺轴激素影响 　　摘要：为研究递增运动负荷对大鼠下丘脑?垂体?肾上腺轴（HPA）与下丘脑?垂体?甲状腺轴（HPT）激素的影响，进一步探讨运动性月经失调（AMI）和HPA、HPT轴激素变化的关系。将成熟、健康的两月龄雌性SD大鼠35只随机分为5组进行研究，结果发现：1) 随着运动负荷递增， ACTH、PRL、TRH、TSH的水平逐渐升高，Ta组大鼠阴道中底层细胞数量逐周增加，第七周最高；2) Ta组血ACTH、PRL与C组相比，存在显著性差异（?P?＜0.05）；Ta组血TSH和C组相比，存在显著性差异（?P?＜0.01）；Tb组血TRH和C组相比，存在显著性差异（?P?＜0.01）。恢复一周后，ACTH、TRH的水平均有所下降。3）经过7周的递增负荷训练，Ta组大鼠肾上腺重量明显高于C组（P?＜0.01），休息一周后略有恢复，但仍高于C组（?P?＜0.05）；Ta组大鼠甲状腺重量明显低于C组（?P?＜0.01）。结论：1) 长期大强度运动导致HPA轴高度活化，肾上腺功能亢进，诱导AMI发生。2) 长期大强度运动导致HPT轴功能紊乱，甲状腺功能减退，诱导AMI发生。3) 提示：AMI是多器官多系统交互作用的结果，HPA轴高度活化、HPT轴功能紊乱及PRL水平升高均可导致AMI的发生。? 　　关键词：动情周期；促肾上腺皮质激素；促甲状腺激素释放激素；促甲状腺激素；催乳素? 　　中图分类号：G804.7文献标识码：A文章编号：1007-3612(2008)01-0050-03? 　　The Effect of Rats in Incremental Graded Exercise on Changes of HPA and HPT Hormones 　　 　　ZHANG Hong?hai?1，WANG Ren?wei?2, HUANG Ya?jun?2, TAN Zhi?zong?1? 　　（1. Shanghai Sports and Health Center, Shanghai 201100, China;?2. Sports Science Department, Shanghai Institute of Physical Education, Shanghai 200438, China）? 　　Abstract:The research was conducted to investigate changes of Hypothalamo?Pituitary?Adrena （HPA） and Hypothalamo?Pituitary?Thyroid （HPT） hormones in incremental graded exercise, as well as the relation between changes of hormones 35 adults and healthy female SD rats were randomly divided into 5 groups. The experiments shows that: 1. The desquamated middle and bottom level cells of vagina increased week by week and reached the highest at seventh week in rats of Ta group; 2. With the increase of exercise load，the level of ACTH，PRL，TRH and TSH increased gradually. ACTH and PRL of Ta group were significantly different with C group （ P＜0.05 ）;TSH of Ta group were significantly different with C group （ P＜0.01 ）;TRH of Tb group were significantly different with C group （ P＜0.01 ）. After 1 week recovery, ACTH and TRH decreased significantly; 3. With the increase of exercise load, the weight of adrenal increased, Ta group were significantly different with C group （P＜0.01）；The weight of thyroid decreased