重楼同属植物长柱重楼与药用重楼药效学对比研究.docVIP

重楼同属植物长柱重楼与药用重楼药效学对比研究 　　[摘要]重楼为多种中成药的原料，由于市场需求量大幅增长，野生重楼资源日益减少，人工栽培生长缓慢，导致重楼资源紧缺。该研究比较了重楼同属植物长柱重楼和药典收载的云南重楼、七叶一枝花在镇痛、抗炎、止血方面的药理活性，以其扩大重楼药用资源范围，保护重楼野生资源，满足市场需求。该实验研究表明长柱重楼和云南重楼、七叶一枝花均具有镇痛、抗炎、止血作用，可明显降低醋酸致小鼠扭体次数，抑制角叉菜胶致大鼠足肿胀和醋酸致小鼠腹腔毛细血管通透性增高，缩短出血时间和凝血时间，且长柱重楼与云南重楼、七叶一枝花的镇痛、抗炎、止血作用相当。 　　[关键词]长柱重楼； 镇痛； 抗炎； 止血 　　Comparative pharmacodynamics study on Paris forrestii and 　　pharmacopoeial Paridis Rhizoma 　　LI Hongmei1， SUN Jianhui1， KANG Liping2， HUO Hairu1， LI Xiaoqin1， 　　HUANG Yuanyuan2， CHEN Min2*， HUANG Luqi2* 　　（1. Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700； 　　2. State Key Laboratory of Daodi Herbs，National Resource Center for Materia Medica， China Academy of 　　Chinese Medical Sciences， Beijing 100700， China） 　　[Abstract]Paris is a raw material of a variety of Chinese medicines， which has become deficient in resource due to market demand substantial growth and wild Paris resources reducing increasingly and the artificial cultivation slow growth This study compared pharmacological activity in analgesia and antiinflammatory and hemostasis effects of P forrestii with pharmacopoeial Paridis Rhizoma to expand its range of Paris medicinal resources and protect wild resources of Paris and meet market demand The experimental study showed that P forrestii and P polyphylla var yunnanensis and P polyphylla var chinensis had analgesic， antiinflammatory and hemostatic effects They can significantly reduce the number of writhing and inhibit rat foot swelling induced by carrageenan and mice capillary permeability induced by acetic acid and short the bleeding time and clotting time Their function is equivalent 　　[Key words]Paris forrestii； analgesia； antiinflammatory； hemostatic effect 　　重?亲魑?一种重要的中成药原料，是云南白药、宫血宁胶囊、季德胜蛇药片、抗病毒颗粒等产品的主要原料。近年来，市场需求量大幅增长，巨大的需求缺口导致药材价格飞涨，大量的采挖使得野生重楼资源日益减少，而人工驯化栽培存在生长缓慢、繁殖率低等困难。为了保护重楼野生资源，满足市场需求，目前对重楼同属植物的化学成分、药理作用、临床应用、资源调查、人工栽培等多方面的研究已广泛开展[1]。 　　《中国药典》[2]2015年版收载的重楼Paridis Rhizoma为百合科植物云南重楼