阿托伐他汀钙治疗慢性阻塞性肺疾病稳定期临床效果研究.docVIP

阿托伐他汀钙治疗慢性阻塞性肺疾病稳定期临床效果研究 　　[摘要]目的 探讨阿托伐他汀钙治疗慢性阻塞性肺疾病（COPD）稳定期的临床疗效情况。方法 分析2015年1月～2017年2月我院心肺康复科收治的120例COPD稳定期患者临床资料，依据治疗方式不同进行分组，常规组（给予常规性治疗）60例和试验组（给予阿托伐他汀钙治疗）60例。观察两组COPD稳定期患者治疗前后血气分析结果、6 min步行试验和肺功能情况。结果 两组患者治疗前PaO2、PaCO2、6 min步行试验、FEV1、FEV1/FVC、FEV1%Pred差异均无统计学意义（P0.05），治疗后常规组和试验组PaO2、6 min步行试验、FEV1、FEV1/FVC、FEV1%Pred均高于治疗前，PaCO2低于治疗前，试验组患者治疗后PaO2、6 min步行试验、FEV1、FEV1/FVC、FEV1%Pred均高于常规组，PaCO2低于常规组，差异均有统计学意义（P0.05）。结论 阿托伐他汀钙治疗COPD稳定期患者，可以改善患者血气分析，提高肺功能，值得临床推广应用。 　　[关键词]阿托伐他汀钙；慢性阻塞性肺疾病稳定期；血气分析；6 min步行试验；肺功能 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721（2017）11（b）-0124-03 　　[Abstract]Objective To approach clinical effects of treatment COPD stabilization by Atorvastatin Calcium.Methods The 120 cases clinical data of COPD stabilization patients in our hospital from January 2015 to February 2017 were analyzed，which was divided into two group by different treatment methods，routine treatment group（routine treatment）60 cases and experimental group（Atorvastatin Calcium treatment）60 cases.The blood gas analysis result，6MWT and lung function of two group COPD stabilization patients before treatment and after treatment were detected.Results The PaO2，PaCO2，6MWT，FEV1，FEV1/FVC，FEV1%Pred of two group COPD stabilization patients before treatment were no difference（P0.05），the PaO2，6MWT，FEV1，FEV1/FVC，FEV1%Pred of routine treatment group and experimental group after treatment were higher than before treatment，PaCO2 was lower than before treatment，the PaO2，6MWT，FEV1，FEV1/FVC，FEV1%Pred of experimental group after treatment were higher than routine treatment group，PaCO2 was lower than routine treatment group，the difference were statistical significance（P0.05）.Conclusion The COPD stabilization by Atorvastatin Calcium，which could improve blood gas analysis，increase lung function，it is worth to be used. 　　[Key word]Atorvastatin Calcium；COPD stabilization；Blood gas analysis；6MWT；Lung function 　　慢性阻塞性肺疾病（COPD）?儆诤粑?内科多发性疾病，其临床特征是气流受到阻塞，随着病情不断的发展和延伸，造成炎性反应不断加重，影响心肺功能[1-2]。随着外周气道阻塞会对肺实质