降尿酸治疗对血液透析患者氧化应激状态改善作用探讨.docVIP

降尿酸治疗对血液透析患者氧化应激状态改善作用探讨 　　【摘要】 目的：观察降尿酸治疗对血液透析（HD）患者氧化应激状态的改善作用。方法：选取51例血尿酸（SUA）480μmol/L的HD患者作为研究对象，平均年龄（51.3±4.9）岁，平均透析年限（3.7±0.8）年，平均周透析时间（11.6±0.9）h。收集治疗前后血标本，检测SUA及氧化应激标志物8-羟基脱氧鸟苷（8-OHdG）和3-硝基酪氨酸修饰蛋白（3-NT）。结果：给予降尿酸治疗后，治疗后患者的SUA值比基线水平（512.4±109.8）μmol/L均显著降低（P0.01），氧化应激标志物8-OhdG为（0.97±0.43）ng/ml，较基线水平（1.93±0.94）ng/ml显著降低（P0.01），与SUA水平呈正相关，相关系数r为0.608，P0.01，而3-NT则无显著性差异[（32.46±9.95）nM vs （29.23±9.63）nM，P=0.104]。结论：降尿酸治疗可改善血液透析患者的氧化应激状态，值得临床推广应用。 　　【关键词】 终末期肾病； 血液透析； 高尿酸血症； 氧化应激 　　中图分类号 R692.6 文献标识码 A 文章编号 1674-6805（2015）14-0001-02 　　Investigation of Urate-lowering Therapy Effect on Blood Oxidative Stress in Hemodialysis Patients/TAN He-zhang，MENG Xiao-yan，HE Qi-feng，et al.//Chinese and Foreign Medical Research，2015，13（14）：1-2 　　【Abstract】 Objective：To investigate the improvement effect of urate-lowering therapy on blood oxidative stress in hemodialysis（HD） patients.Method：51 HD patients who had serum uric acid （SUA） levels above 480 μmol/L in our hospital were selected as research objects，the mean age was （51.3±4.9）years，the mean HD duration was （3.7±0.8）years，the mean dialysis time per week was （11.6±0.9）hours.Blood samples were collected for detecting SUA and oxidative stress markers（8-OhdG and 3-NT） before and after the treatment.Result：After urate-lowering therapy，the level of SUA in HD patients decreased significantly（P0.01），comparing with the baseline level （512.4±109.8）μmol/L.The oxidative stress markers 8-hydroxy deoxyguanosine （8-OhdG ） also decreased significantly，comparing with the baseline level [（1.93±0.94）ng/ml vs （0.97±0.43）ng/ml， P0.01]，which were positively correlated with the level of SUA，the correlation coefficient was 0.608，P0.01.However，the 3-nitrotyrosine modified protein （3-NT） was not significantly different from its baseline level [（32.46±9.95）nM vs （29.23±9.63）nM，P=0.104].Conclusion：Urate-lowering therapy can ameliorate the oxidative stress status in HD patients，is worthy of clinical application. 　　【Key words】 End-stage renal dis