降钙素原C反应蛋白与线粒体DNA水平检测在老年脓毒症多器官功能衰竭病情评估中应用.docVIP

降钙素原C反应蛋白与线粒体DNA水平检测在老年脓毒症多器官功能衰竭病情评估中应用 　　[摘要]目的 探?降钙素原（PCT）、C反应蛋白（CRP）与线粒体DNA（mt-DNA）水平检测在老年脓毒症多器官功能衰竭（MODSE）病情评估中的应用价值。方法 选取2014年1月～2016年12月我院收治的62例老年脓毒症患者，将其中合并器官功能衰竭的29例患者设为衰竭组，未合并器官功能衰竭的33例患者设为未衰竭组；选取同期的30例正常体检者作为对照组。比较三组受检者的PCT、CRP、mt-DNA水平差异。结果 脓毒症患者的PCT、CRP、mt-DNA水平均显著高于对照组（P0.05）。根据器官衰竭情况进一步分组，分为单器官衰竭组（11例）、双器官衰竭组（9例）、三个及以上器官衰竭组（9例），随着衰竭器官数量的增多，患者的mt-DNA、PCT水平也显著增高，各组间比较差异均有统计学意义（P0.05）。结论 PCT、CRP及mt-DNA均能提示老年患者脓毒症的发生，PCT、mt-DNA水平测定不但能够用于脓毒症的诊断，更能够用于老年脓毒症患者器官功能衰竭情况的评估，值得在临床中推广和应用。 　　[关键词]脓毒症；多器官功能衰竭；老年；降钙素原；C反应蛋白；线粒体DNA 　　[中图分类号] R592 [文献标识码] A [文章编号] 1674-4721（2017）10（c）-0123-03 　　Application of procalcitonin，C-reactive protein and mitochondrial DNA level test in the assessment of multiple organ dysfunction in elderly patients with sepsis 　　LIAO Xiao-long GUO Wei-xin WANG Zhong-hua LIANG Jun WANG Shou-hong 　　Institute of Geriatrics，People′s Hospital of Guangdong Province （Guangdong Academy of Medical Sciences），Guangzhou 510080，China 　　[Abstract]Objective To explore the application values of procalcitonin （PCT），C-reactive protein （CRP） and mitochondrial DNA （mt-DNA） level test in the assessment of multiple organ dysfunction in multiple organ dysfunction in elderly （MODSE） patients with sepsis.Methods From January 2014 to December 2016，62 elderly patients with sepsis admitted into our hospital were selected as research objects.Among them，29 patients complicated with organ failure were classified into the failure group，and the rest was categorized into the non-failure group.Meanwhile，another group of 30 healthy participants after physical examinations was classified into the control group.The differences of PCT，CRP，and mt-DNA levels were compared.Results The levels of PCT，CRP and mt-DNA levels in sepsis patients were significantly higher than those in the control group （P0.05）.According to the conditions of organ failure，the patients were further divided into the single-organ failure group （n=11），the double-organ failure group （n=9），and the three or