院内感染细菌耐药性与抗生素使用强度临床研究.docVIP

院内感染细菌耐药性与抗生素使用强度临床研究 　　【摘要】 目的 探讨院内细菌感染耐药性与抗生素使用强度的关联性， 为规范使用抗生素提供参考依据。 方法 回顾医院院内感染细菌培养结果及其耐药情况， 调查细菌耐药倾向， 研究抗生素使用强度与细菌耐药率的内在关联性；同时将基础用药比率与抗生素使用强度作横向对比， 讨论基本药物使用比率与细菌耐药率的内在联系。 结果 抗生素使用强度50用药频度（DDDs）的菌种其耐药率明显高于抗生素使用强度为30 DDDs的菌种， 差异有统计学意义（P50%， 抗生素使用强度明显下降， 基本药物使用比率与抗生素使用强度呈明显负相关（r=-5.61， P0.05）。 ?Y论 高强度抗生素使用催生了耐药菌株的增长， 规范抗生素运用显得十分迫切， 适当增加基本药物使用比率， 能够抑制抗生素的过分使用。 　　【关键词】 院内细菌感染；耐药菌；抗生素使用强度 　　DOI：10.14163/j.cnki.11-5547/r.2017.02.008 　　Clinical study of drug resistance in nosocomial infection bacteria and antibiotic use intensity XU Wei-li， YAO Xue-gan， ZHAO Zhan-jing. Shenzhen City Dapeng New District Maternal and Child Health Hospital， Shenzhen 518120， China 　　【Abstract】 Objective To investigate correlation between drug resistance in nosocomial bacterial infection and antibiotic use intensity， in order to provide reference for standardizing the use of antibiotics. Methods Bacterial culture outcomes and drug resistance in nosocomial bacterial infection in recent 3 years were retrospectively analyzed to study bacterial drug resistance tendency and to research internal correlation between antibiotic use intensity and bacterial drug resistance rate. Lateral comparison was made between basic medicine usage rate and antibiotic use intensity to discuss internal correlation between basic medicine usage rate and bacterial drug resistance rate. Results Bacteria with antibiotic use intensity 50 defined daily doses （DDDs） showed obviously higher drug resistance rate than bacteria with antibiotic use intensity as 30 DDDs， and the difference had statistical significance （P 50% led to obviously decreased antibiotic use intensity， therefore basic medicine usage rate as significantly negatively correlated with antibiotic use intensity （r=-5.61， P0.05）. Conclusion Due to increased drug-resistance bacteria induced by high antibiotic use intensity， it is essential to standardize antibiotic use. Proper increasing of basic medicine usage rate can inhibit antibiotic overuse. 　　【Key