高血压合并冠心病患者心功能与D―二聚体检验水平相关研究.docVIP

高血压合并冠心病患者心功能与D―二聚体检验水平相关研究 　　[摘要] 目的 探讨高血压合并冠心病患者血液D-二聚体的对病情预测的临床价值。 方法 选取2012年1月―2015年6月河南省鹤壁市人民医院心内科收治的200例高血压合并冠心病患者作为观察组，选择同期单纯原发性高血压者200例作为对照组，检测两组患者的血清D-二聚体水平。 结果 观察组的D-二聚体水平（297.68±75.44）μg/L明显高于对照组（69.54±22.19）μg/L，差异有统计学意义（t=4.284，P0.05）。对于高血压合并冠心病患者，随着心功能的减退，D-二聚体水平水平增加，D-二聚体与心功能等级呈正相关（r=0.493，P0.05）。 结论 D-二聚体及心肌损伤指标关系密切，表明炎症与血栓形成及心肌损伤关系密切；D-二聚体与心功能等级密切相关，心功能不全可能是D-二聚体水平升高的重要诱因。 　　[关键词] 高血压合并冠心病；诊断；D-二聚体 　　[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742（2016）05（a）-0061-03 　　[Abstract] Objective To discuss the clinical value of blood D-dipolymer of patients with hypertension and coronary heart disease in predicting the disease condition. Methods 200 cases of patients with hypertension and coronary heart disease admitted and treated in the department of cardiology of our hospital from January 2012 to June 2015 were selected as the observation group， 200 cases of patients with simple primary hypertension treated at the same period were regarded as the control group， and the serum D-dipolymer levels of the two groups were tested. Results The D-dipolymer level in the observation group was obviously higher than that in the control group[（297.68±75.44） μg/L vs （69.54±22.19） μg/L]， and the difference had statistical significance， （t=4.284， P0.05）， for patients with hypertension and coronary heart disease， with the decrease of cardiac function， D-dipolymer level increased， and D-dipolymer was positively correlated with the cardiac function grading， （r=0.493， all P0.05）. Conclusion The close correlation between D-dipolymer and myocardiac injury index indicates that the correlation between inflammation and thrombogenesis and myocardiac injury is close， D-dipolymer is closely correlated with the cardiac function grading and cardiac insufficiency may be the important cause of the increase of D-dipolymer level. 　　[Key words] Hypertension and coronary heart disease； Diagnosis； D-dipolymer 　　随着人们生活节奏的加快，生活压力较大，许多传统疾病会在人群中出现新的表现特点，许多疾病的合并症较多，其中高血压病是临床常见病，高血压常常合并多种并发症或者合并