高通量透析对尿毒症维持性血液透析患者血清HCYβ2―MGCysC影响.docVIP

高通量透析对尿毒症维持性血液透析患者血清HCYβ2―MGCysC影响 　　[摘要] 目的 研究高通透量透析对尿毒症维持性血液透析患者血清HCY、β2-MG、CysC的影响。 方法 选取2010年1月～2015年12月在我院接受维持性血液透析治疗的尿毒症患者80例，按随机数字表法将患者分为高通量组和低通量组，各40例，分别检测两组患者透析前及透析后3、6个月的血清HCY、β2-MG、CysC含量，分析其变化。 结果 高通量组患者透析后血清HCY、β2-MG、CysC水平较透析前明显下降（P均0.05），高通量组透析后血清HCY、β2-MG、CysC水平明显低于低通量组（P均0.05）。 结论 高通量透析后尿毒症维持性血液透析患者血清HCY、β2-MG、CysC水平显著下降。 　　[关键词] 高通量血液透析；低通量血液透析；维持性血液透析；尿毒症 　　[中图分类号] R459.5 [文献标识码] A [文章编号] 1674-4721（2016）04（c）-0030-03 　　Impact of high flux dialysis on the serum HCY，β2-MG and CysC of uremia patients with maintenance hemodialysis 　　ZOU Li-e ZHONG Zheng-xin WANG Chun-feng LIAO Wei-qun 　　Department of Nephrology，Traditional Chinese Medicine Hospital of Huizhou City in Guangdong Province，Huizhou 516001，China 　　[Abstract] Objective To study the impact of high flux dialysis on the serum HCY，β2-MG and CysC of uremia patients with maintenance hemodialysis. Methods 80 uremia patients with maintenance hemodialysis from January 2010 to December 2015 of our hospital were selected and were divided into high flux group and low flux group according to random number table.Each group was 40 cases.The serum HCY，β2-MG and CysC content of maintenance hemodialysis patients were tested at pre-dialysis and 3，6 months after dialysis and the changes were compared. Results The serum level of HCY，β2-MG and CysC in high flux group decreased obviously compared with before dialysis（all P0.05）.The serum level of HCY，β2-MG and CysC in high flux group was obvious lower than that in low flux group respectively when compared between two groups（all P0.05）. Conclusion The serum HCY，β2-MG and CysC level of uremia patients with maintenance hemodialysis decrease obvious after high flux dialysis. 　　[Key words] High flux hemodialysis；Low flux hemodialysis；Maintenance hemodialysis；Uremia 　　随着人口老龄化和生活方式的改变，慢性肾脏病在全球的患病率逐年增高，维持性血液透析（maintenance hemodialysis，MHD）成为终末期肾病患者的肾脏替代治疗方法，应用此疗法患者的生活质量得到了提高，寿命得以显著延长，但普通的血液透析仅能吸附分子量小、与血浆蛋白结和低的水溶性毒物，代谢产物和药物，但不能有效降低血磷浓度[1]，不能彻底清除中大分子毒素，其中以高同型半胱氨酸（