创新与医疗发展医学培训课件.ppt

在中国招募人才在美国接受培训 我们正在为中国的年轻科学家和医学科学家寻求创建一个培养项目，可以将他们培养成未来中国转化医学的领导者。 国际平台 国际转化医学联盟(International Coalition of Translational Medicine, ICTM) 由中美专家共同发起，总部设在费城和北京。旨在加强国际合作，推动转化医学发展，将创新尽快转化临床，推动医学的发展。现任临时联盟主席是北京首都医科大学世纪坛医院的李天佐教授，现任临时秘书长是宾夕法尼亚大学的刘仁玉教授。ICTM的第一份官方杂志为《围术期疼痛和转化医学》。现由宾夕法尼亚大学的刘仁玉教授和罗格斯新泽西医科大学的陶元祥教授共同主编。 联盟网址 杂志网址 Opioid and Opioid Receptor Pharmacology Welcome to Liu’s Lab Structure, function, and Novel targets Collaborators Jeffery Saven (Chemistry, UPENN) Joshua Wand (Biophysics, UPENN) Yeliseev, Alexei (Protein Science, NIH) Bryan Roth (Pharmacology, University of North Carolina) Julie Blendy (Pharmacology, UPENN) A. T. Charlie Johnson, Jr., (Physics and Astronomy, UPENN) Opioid in surgical patients and outcome Collaborators Eric Zager (Neurosurgery, UPENN) Hossain, Erik (EPIC Report, UPENN) Report in the news Salvinorin A from the plant Structure of Mu receptor Broad range publications with highest impact factor of 13.3 so far wsMUR as a novel tool for strcture function studies Fig 2a Fig 2b 1. Zhao X. et al. Anesthesiology. 2014 Oct;121(4):866-75. 2. Lerner MB. Nano Lett. 2014 May 14;14(5):2709-14 Novel Targets for opioids? Liu R. et al. Novel molecular targets of dezocine and their clinical implications. Anesthesiology. 2014 Mar;120(3):714-23.. Novel Targets for morphine? Salvinorin A: Kappa opioid receptor agonist Salvinorin A is the active component of Salvia Divinorum, a natural plant that was discovered by Wasson and Hofmann in 1962 2002, Salvinorin A is proven to be the most highly efficacious, naturally-occurring, nonpeptide, non-opioid KOR agonist. Structure of salvinorin A Salvinorin A as a potent Kappa Agonist Roth BL, et al. PNAS 2002, 99 (18): 11934–11939 The cerebral vascular dilatation effects of salvinorin A Actual image of the pial artery comparison before (left panel) and after (right panel) salvinorin administration in a resting tone condition. TTC staining. Note that the white infarcted area in the brain is almost completely gon