加味左金丸治疗肝胃不与型反流性食管炎临床观察.docVIP

加味左金丸治疗肝胃不与型反流性食管炎临床观察 　　摘要：目的 观察加味左金丸联合西药治疗肝胃不和型反流性食管炎的临床疗效。方法 将90例患者随机分为观察组和对照组，每组45例。对照组予雷贝拉唑钠肠溶胶囊和多潘立酮片，观察组在对照组治疗基础上给予加味左金丸治疗，连用4周。观察2组患者的临床疗效?治疗前后的中医证候积分及胃镜改善效果。结果 临床疗效比较，观察组总有效率为95.5%（43/45），对照组为93.3%（42/45），差异无统计学意义（P0.05）；观察组显效率为77.8%（35/45），对照组为57.8%（26/45），差异有统计学意义（P0.05）。治疗后2组中医证候积分均有改善（P0.001），观察组优于对照组（P0.05）。胃镜下食管炎症改善程度比较，观察组总有效率为96.5%（43/45），对照组为77.8%（35/45），差异有统计学意义（P0.05）。结论 加味左金丸联合西药治疗反流性食管炎有较好的疗效。 　　关键词：加味左金丸；反流性食管炎；肝胃不和 　　DOI：10.3969/j.issn.1005-5304.2014.06.013 　　中图分类号：R259.71 文献标识码：A 文章编号：1005-5304（2014）06-0035-03 　　Abstract：Objective To observe the clinical effect of Jiawei Zuojin Pills combined with western medicine on reflux esophagitis with liver-stomach disharmony syndrome. Methods Totally 90 cases were divided into observation group （45 cases） and control group （45 cases）. The control group was given rabeprazole sodium enteric-coated capsule and domperidone tablets， and the observation group was given Jiawei Zuojin Pills additionally for four weeks. The clinical effect， TCM syndrome score and endoscopic improvement were observed. Results The total effective rate of observation group was 95.5% （43/45）， control group was 93.3% （42/45）， with no significant difference between the two groups （P0.05）. The excellent rate of observation group was 77.8% （35/45）， control group was 57.8% （26/45）， with significant difference （P0.05）. TCM syndrome score was improved in both groups （P0.001）， and the degree of improvement in the observation group was better than control group （P0.05）. The total effective rate rate under endoscopic of observation group and control group was 96.5% （43/45） and 77.8% （35/45） respectively， with significant difference （P0.05）. Conclusion Jiawei Zuojin Pills combined with western medicine has obvious efficacy in treating reflux esophagitis with liver-stomach disharmony syndrome. 　　Key words：Jiawei Zuojin Pills；reflux esophagitis；liver-stomach disharmony 　　反流性食管炎（reflux esophagitis，RE）是由于胃十二指肠内容物反流入食管，引起食管黏膜损伤而出现的疾病，表现为胸