2015-16-2 胰岛素及口服降糖药课件.ppt

37 胰岛素和抗糖尿病药Insulin Antidiabetic Drugs;Diabetes Mellitus;Diabetes Mellitus;Diabetes Mellitus;ADA Classification of Diabetes;Charles Best (left) and Frederick Banting (right) Extracted insulin and treated dogs (1921) ;;胰岛素Insulin;Stage 1 Insulin was extracted from the glands of cows and pigs. (1920s) Stage 2 Convert pig insulin into human insulin by removing the one amino acid that distinguishes them and replacing it with the human version. ;Stage 3 Insert the human insulin gene into E. coli and culture the recombinant E.coli to produce insulin (trade name = Humulin?). Yeast is also used to produce insulin (trade name = Novolin?) (1987). ;;Insulin;Diabetes Mellitus;Insulin;Mechanism of Insulin Action;Insulin; 胰岛素 — [基本特征];Insulin;*;*;Pre-mixed Insulin;Normal Insulin Profiles;;Insulin;第二节 口服降糖药 ;Type 2 Diabetes;;Oral Hypoglycemic Drugs磺酰脲类： ----sulfonylureas;Oral Hypoglycemic Drugs ----sulfonylureas;【作用机制】;Mechanism of Insulin Release in the Pancreas;Oral Hypoglycemic Drugs ----sulfonylureas;Oral Hypoglycemic Drugs ----sulfonylureas;Oral Hypoglycemic Drugs ----sulfonylureas;Oral Hypoglycemic Drugs ----sulfonylureas;Oral Hypoglycemic Drugs双胍类： ----biguanides;Oral Hypoglycemic Drugs ----biguanides;Oral Hypoglycemic Drugs ----biguanides;Oral Hypoglycemic Drugs ----biguanides;胰岛素增敏剂： 噻唑烷二酮类--thiazolidinediones;Oral Hypoglycemic Drugs --thiazolidinediones; thiazolidinediones;Oral Hypoglycemic Drugs --α-glucosidase inhibitors;Oral Hypoglycemic Drugs --α-glucosidase inhibitors;糖尿病的治疗原则;THE END!!!!