白三烯动态变化和小儿上呼吸道感染关系研究.docVIP

白三烯动态变化和小儿上呼吸道感染关系研究 　　[摘要] 目的 探讨白三烯（LTs）在小儿上呼吸道感染中的变化特征及其意义。 方法 回顾性分析本院2009年6月～2010年10月收治入院的急性上呼吸道感染患儿46例临床资料，选择本院同期正常体检儿童46例做为对照组。所有患儿分别用双核夹心ELISA法测定急性期及恢复期血、尿白三烯的水平。 结果 上呼吸道感染患儿在急性期血、尿中白三烯水平显著高于健康儿童，而恢复期与健康儿童差异无统计学意义。上呼吸道感染时白细胞计数大于10×109时显示血、尿LTs水平明显增加，P 0.05。 结论 白三烯参与上呼吸道感染的发病过程，白三烯受体拮抗剂在上呼吸道感染治疗上可能有一定作用。 　　[关键词] 白三烯；上呼吸道感染；趋化作用；儿童 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2012）02（a）-0088-02 　　 　　Clinical study on leukotrienes in children with upper respiratory tract infection 　　WANG Yi 　　The Second Nuclear Hospital Grassroots Clinics of Bali Village Streets in Haidian District of Beijing City, Beijing 100840, China 　　[Abstract] Objective To investigate the change character and significance of leukotriene of children with the upper respiratory tract infection. Methods The clinical data of 46 cases of children with acute upper respiratory tract infection in our hospital in June 2009 to October 2010 was analyzed, 46 cases of normal children were chosen as control group. Blood and urine leukotriene level of them were detected with dual-core sandwich ELISA method in the acute and recovery phase. Results Blood, urine leukotriene level of children in the acute phase was significantly higher than healthy children, and that of recovery phase and healthy children has no significant differences. Blood and urine LTs level increased obviously when white blood count was more than 10×109, P 0.05. Conclusion Leukotriene participates in the process of the upper respiratory tract infection, leukotriene receptor antagonists may have had some effect in the upper respiratory tract infection treatment. 　　[Key words] Leukotriene; The upper respiratory tract infection; Chemotaxis role; Children 　　 　　上呼吸道感染是小儿最常见的疾病，其病原体90%以上是病毒。半胱氨酸白三烯（LTs）是一组炎症介质，对嗜酸粒细胞有很强的趋化作用，白三烯水平升高，表明病毒感染可能诱发白三烯释放增加，并与哮喘炎症细胞浸润有关[1-3]。本试验用ELISA法监测46例上呼吸道感染患儿急性期及恢复期血、尿白三烯的浓度与正常儿童作对照，探讨其在发病机制中作用及临床意义。 　　1 资料与方法 　　1.1 一般资料 　　选取本院2009年6月～2010年10月收治入院的急性上呼吸道感染患儿46例，其中，男26例，女20例，年龄最大11岁，最小1.5岁，平均年龄（5.