西咪替丁和临床常用维生素及高危药品配伍稳定性分析.docVIP

西咪替丁和临床常用维生素及高危药品配伍稳定性分析 　　[摘要] 目的 考察西咪替丁与临床常用维生素（维生素C和维生素B6）、高危药品（异丙嗪和酚妥拉明）在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。 方法 按照临床常用药物浓度配制相应药物溶液以及西咪替丁与各药物的配伍液，采用紫外分光光度法建立西咪替丁与上述药物的含量测定方法，在（25±2）℃条件下，于0、2、4、6 h取样观察配伍液的外观、pH值以及含量的变化。 结果 配伍液静置6 h后，西咪替丁与维生素C、维生素B6、异丙嗪、酚妥拉明药物配伍溶液颜色无明显变化，无气泡以及沉淀生成;各组配伍液在室温放置6 h内pH均无明显变化;各组药品配伍液在6 h内含量无明显变化。 结论 西咪替丁与上述药物在室温放置6 h后配伍液相对较稳定，无物理性配伍禁忌。 　　[关键词] 西咪替丁;维生素;高危药品;配伍稳定性;紫外分光光度法 　　[中图分类号] R978.1 [文献标识码] A [文章编号] 1673-7210（2015）01（a）-0102-07 　　Study on the compatible stability of Cimetidine with common Vitamins and high-risk drugs 　　ZHANG Huizhi1 ZHANG Ying1 YANG Rui2 SUN Huibin1 　　1.Department of Pharmacy， Zhengzhou Second Hospital， He′nan Province， Zhengzhou 450006， China; 2.Department of Pharmacy， the People′s Hospital of Jingdong Yi Minority Autonomous County in Puer City， Yunnan Province， Jingdong 676200， China 　　[Abstract] Objective To determine the stability of the compatibility of Cimetidine with clinical commonly used Vitamin （Vit C and Vit B6）， high-risk drugs （promethazine and phentolamine） in 0.9% sodium Chloride Injection or in 5% Glucose Injection. Methods The corresponding drug infusion and the compatibility of Cimetidine with each drug were made according to the drug concentration of clinical application， and then UV spectrophotometry was adopted to construct the methods for the determination of Cimetidine， Vit C， Vit B6， promethazine and phentolamine. The appearance， pH and drug content were observed and determined at 0， 2， 4， 6 h at temperature of （25±2）℃. Results The compatibility of Cimetidine with Vit C， Vit B6， promethazine and phentolamine drugs had no obvious change， no bubbleand sediment in 6 h. And there were aslo no significant changes in pH， drug content for the compatible stability of infusion in 6 h. Conclusion The stability of the compatibility of Cimetidine with above-mentioned drugs is good， and has no physical taboos. 　　[Key words] Cimetidine; Vitamin; High-risk drugs; Compatible sta