壮药海南茄质量标准初步的研究.docVIP

壮药海南茄质量标准初步的研究 　　【摘 要】 目的：对海南茄药材质量标准进行初步研究。方法：对海南茄进行化学成分预试验和薄层色谱鉴别研究，并按 2015年版《中华人民共和国药典》（四部）方法对海南茄的水分、总灰分、酸不溶性灰分、醇溶性浸出物含量进行测定。结果：初步明确了海南茄化学成分类型并建立薄层色谱鉴别方法，确定海南茄药材水分、总灰分、酸不溶性灰分、浸出物限量，初步拟定海南茄药材水分不得超过15.0%，总灰分不得超过9.0%，酸不溶性灰分不得超过1.0%，醇溶性浸出物不得少于2.5%。结论：所建立的方法可为海南茄药材质量标准的制定提供实验依据。 　　【关键词】 海南茄；化学成分；预试验；薄层色谱；质量标准 　　【中图分类号】R284.1 【文献标志码】 A 【文章编号】1007-8517（2017）09-0020-03 　　Preliminary Study On Quality Standards of Solanum procumbens Lour 　　HUANG Lin yun1 HUANG Rui song1* LI Xiao qun2 　　1. Guangxi Research Institute of Minority Nationality Medicine and Pharmacology，Nanning 530001， China；2. Guangxi University，Nanning 530004， China 　　Abstract：Objective To conduct a preliminary study on quality standards of Solanum procumbens Lour.Methods Preliminary tests and TLC identification for the chemical constituents of Solanum procumbens Lour were performed. Determination of moisture， total ash， acid insoluble ash and extractives in Solanum procumbens Lour was studied based on appendix of Chinese Pharmacopoeia， published in 2015. Results Its chemical constituents were initially determined and TLC identification was set up. Moisture in Solanum procumbens Lour should be less than or equal to 15.0%，with the total ash content less than or equal to 9.0% and the content of acid insoluble ash less than or equal to 1.0%.And the content extracted from Solanum procumbens Lour by the hot-dip method with alcohol being used as solvent should be greater than or equal to 2.5%. Conclusion The established methods can provide the experimental foundation to formulate quality standards for Solanum procumbens Lour. 　　Keywords：Solanum procumbens Lour；Chemical Constituents；Preliminary Tests；TLC；Quality Standards 　　海南茄?楣阄髯匙迕窦涑Ｓ靡┎模?又名猫猪?{、金耳环、耳环锤，为茄科植物海南茄Solanum procumbens Lour.的全株，在广西主要分布于北海、防城港、合浦等沿海地区[1]。其味微苦、凉，有小毒，壮医认为具有通火路、清热毒、消肿痛、利咽喉的功效，用于货烟妈（咽痛），呗嘻（乳痈），林得叮相（跌打损伤），额哈（毒蛇咬伤）等病症[2]。有文献对海南茄的显微鉴别进行报道[3]，但关于该药材化学成分及质量标准方面的研究未见有报道。为保证其用药的安全性、有效性，本论文对其进行化学成分预试验，建立薄层色谱（TLC）鉴别方法，测定8批样品水分、总灰分、酸不溶性灰分、醇溶性浸出