基于IgG抗A效价梯度及动态差值的探讨ABO―HDN病情相关性.docVIP

基于IgG抗A效价梯度及动态差值的探讨ABO―HDN病情相关性 　　[摘要] 目的 探讨动态监测IgG抗A（B）效价梯度与ABO-HDN病情严重程度临床指标的相关性。 方法 选取2017年1～5月间47例ABO溶血病患儿临床资料进行统计分析，记录患儿出生后32 h的血清总胆红素（serum total bilirubin，STB32h）、血红蛋白（hemoglobin，Hb）、网织红细胞百分比（the percentage of reticulocyte，Ret%）及孕妇第16和37周IgG抗A（B）效价梯度。比较各组新生儿临床指标和lgG抗A（B）效价的相关性。 结果 STB32h与37周IgG抗A（B）效价梯度、IgG抗A（B）37-16梯度差呈正相关（P0.001）；Hb与第37周IgG抗A（B）效价梯度呈负相关（r2=0.2074，P=0.0013）；Hb与IgG抗A（B）37-16梯度差值呈负相关（r2=0.1831；P=0.0027）；Ret%与37周IgG抗A（B）效价梯度、IgG抗A（B）37-16梯度差值呈正相关（P0.001）。 结论 产前37周IgG抗A（B）效价梯度、IgG抗A（B）37-16效价梯度差值与新生儿ABO-HDN的病情严重程度具有一定相关性。 　　[关键词] ABO溶血病；STB32h；IgG抗A（B）效价；IgG抗A（B）37-16效价梯度差 　　[中图分类号] R725.5 [文献标识码] A [文章编号] 1673-9701（2017）29-0035-03 　　Exploration of the correlation of ABO-HDN disease based on IgG anti-A（B）potency gradient and dynamic difference 　　SHEN Jian1，2 SHI Xinwei3 CHEN Bingyu1，2 WANG Zhen1，2 　　1.Department of Blood Transfusion， Zhejiang Provincial Peoples Hospital， Peoples Hospital of Hangzhou Medical College， Hangzhou 300014， China； 2.Operating Room， Zhejiang Provincial Ophthalmologic Hospital， Hangzhou 300014， China 　　[Abstract] Objective To investigate the correlation between dynamic monitoring of IgG anti-A （B）potency gradient and clinical indexes of ABO-HDN severity. Methods A total of 47 patients with ABO hemolytic disease from January to May 2017 were analyzed statistically. The serum total bilirubin（STB32 h）， hemoglobin（hemoglobin， Hb） and the percentage of reticulocyte（Ret%） at 32 h after birth of children， and the 16th and 37th week IgG A（B） potency gradient in pregnant women were recorded. The neonatal clinical indicators and anti-A（B） titers in newborns of each group were compared. Results There was a positive correlation between STB32h and the 37-week IgG A（B）titer gradient， IgG A（B）37-16 gradient difference（P0.001）. Hb was negatively correlated with the 37th week IgG A（B） potency gradient（r2=0.2074， P=0.0013）. Hb was negatively correlated with IgG A（B）37-16 gradient difference（r2=0.1831， P=0.0027）. Ret% was positively