多模态图像配准研究及其在超声热导向药物靶向治疗中的应用-生物医学工程专业论文.docxVIP

对准肿瘤部位进行治疗。 其次，软组织器官在术中会产生形变，而这种形变仅仅用刚性变换 来描述是不够的。为此，本文进一步研究了基于互信息的非刚性图像配 准算法。基于互信息的图像配准不需要对不同成像模式下的图像灰度间 的关系作任何假设, 也不需要对图像进行分割或提取等预处理, 所以被 广泛地用于医学图像配准处理。在讨论基于互信息的图像配准算法和配 准中常用的插值算法的基础上，研究了互信息图像配准中的局部极值现 象及其产生原因，并提出一种新的基于Hanning窗的部分体积插值算法 （Partial Volume Interpolation）。二维刚性图像配准实验证明，该插值算 法可以有效抑制互信息目标函数的局部极值，防止优化搜索陷入局部最 优。 本文将此插值算法应用到三维非刚性图像配准中，改进了基于互信 息和自由变形模型的非刚性图像配准算法。在配准过程中，增加了平滑 约束项，进一步抑制局部极值。配准算法采用梯度下降法最小化目标函 数。设计了两个实验对配准方法进行评价, 从实验结果看这种方法在配 准精度上优于经典算法。 关键词：药物靶向治疗，多模态医学图像配准，互信息，插值，自 由变形模型 INVESTIGATION ON MEDICAL IMAGE REGISTRATION AND APPLICATION IN HEAT-TRIGGERED DRUG TARGETING USING ULTRASOUND PHASED ARRAY ABSTRACT In heat-triggered drug targeting using ultrasound ，Chemotherapeutic agents is encapsulated in thermo sensitive liposome and then delivered to tumor. Array phased ultrasound can heat the targeted area. The heat induced by ultrasound can open the capsule then release the chemotherapeutic agents in expected area. This technology can not only increase the local concentration of chemotherapeutic agents, but also prevent the whole body damaged by chemotherapeutic agents. Also, the heat can sensitize the released chemotherapeutic agents. In order to protect normal tissues and increase the treatment efficiency, we must have an exact understanding of location of the targeted area. But the current ultrasound imaging technique can not do it alone. In this paper, we exploited the image guided localization system based on multimodality image registration. Firstly, we researched the design and implementation of the image guided localization system based on multimodality image registration. We segment tumor in higher -resolution CT image and then registered it with the ultrasound images. Then the contour of the tumor in pre-operation CT images can be transferred to that in intra-operation ultrasound image automatically and precisely. With the guidance of this contour information, the focus of the transducer can be set on tumor and targeting hyperthermia begins.