常压离子源在药物-血浆蛋白亲和力考察和游离血药浓度检测中的应用-药物分析专业论文.docxVIP

中国食品药品检定研究院 中国食品药品检定研究院 万方数据 万方数据 目录 HYPERLINK \l _bookmark0 摘要··············································································································· 3 HYPERLINK \l _bookmark1 Abstract 5 HYPERLINK \l _bookmark2 第一章 解吸附电喷雾质谱高通量检测药物-负电位点蛋白亲和力································· 7 HYPERLINK \l _bookmark3 1.1 本章引言 ····························································································· 7 HYPERLINK \l _bookmark4 1.2 实验部分 ····························································································10 HYPERLINK \l _bookmark5 1.2.1 试剂与仪器 ·················································································10 HYPERLINK \l _bookmark6 试剂··················································································10 HYPERLINK \l _bookmark7 仪器··················································································10 HYPERLINK \l _bookmark8 1.2.2 DESI-MS 分析平台的搭建与仪器参数的设置 10 HYPERLINK \l _bookmark9 1.2.3 分析样品的制备 ···········································································12 HYPERLINK \l _bookmark10 复合物体系的制备································································12 HYPERLINK \l _bookmark11 置换体系的制备···································································13 HYPERLINK \l _bookmark12 待测药物纯品对照体系的制备·················································13 HYPERLINK \l _bookmark13 分析样品板的制备································································13 HYPERLINK \l _bookmark14 1.2.4 解吸附电喷雾质谱分析 ··································································13 HYPERLINK \l _bookmark15 1.3 结果与讨论 ··························································································13 HYPERLINK \l _bookmark16 1.3.1 应用解吸附电喷雾质谱研究九种药物与三种正电位点蛋白的结合力以及验证 HYPERLINK \l _bookmark16 洗涤步骤····························································································13 HYPERLINK \l _bookmark17 1.3.2 应用解吸附电喷雾质谱研究（R），（S）-氨氯地平与负电位点蛋白 α1-酸性糖 HYPERLINK