柴胡坤草汤治疗黄褐斑（气滞血瘀型）的临床疗效观察-中医外科学专业论文.docxVIP

成都中医药大学硕士学位论文 成都中医药大学硕士学位论文 万方数据 万方数据 中文摘要 目的：观察柴胡坤草汤治疗黄褐斑（气滞血瘀型）的临床疗效，初步探讨其作 用机理。 方法：采用随机对照试验，计算样本量后选取 60 例气滞血瘀型女性黄褐斑患者， 根据随机数字表分为两组，每组各 30 例，治疗组予口服柴胡坤草汤，每日 1 剂， 水煎服（煎药机代煎），每次 1 袋，约 200ml，每日 3 次，局部外擦 2%氢醌乳膏， 每日 2 次；对照组无内服药，局部外擦 2%氢醌乳膏，每日 2 次。两组均以 1 个 月为 1 疗程，治疗 3 个疗程后，比较皮损颜色、面积和兼症的变化，判定疗效。 结果：治疗组脱落 2 例，共完成病例 28 例，其中痊愈 3 例（10.71%），显效 8 例（28.57%），有效 13 例（46.42%），无效 4 例（14.28%），总有效率为 85.71%； 对照组脱落 1 例，共完成病例 29 例，痊愈 1 例（3.44%），显效 5 例（17.24%）， 有效 13 例（44.82%），无效 10 例（11.49%），总有效率为 65.52%。经统计学 分析，P0.05，比较差异有统计学意义，说明治疗组的疗效优于对照组。 结论：柴胡坤草汤是治疗女性黄褐斑（气滞血瘀型）的有效方，治疗效果较好， 无明显不良反应，具有临床推广意义。 关键词：黄褐斑；气滞血瘀型；柴胡坤草汤；临床观察。 Abstract Objective: To study the clinical efficiacy and pharmacological mechanism of radix bupleuri motherwort decoction for treating melasma with qi stagnation and blood stasis． Methods: The cases of this study are typical chloasma patients who are from the first Affiliated Hospital of Chengdu University of Chinese Medicine from January to December 2014 for medical treatment.They are diagnosed qi stagnation and blood stasis according to Chinese Medicine standard. The sixty patients were devided into two groups.The Treating Group and the Contrasting Group，each of which has thirty patients．The treating group are given radix bupleuri motherwort decoction to take for three months ． They should take one bag of radix bupleuri motherwort decoction each day，and three times a day，and 180ml each time．Both groups are given 2% Hydroquinone cream to wipe skin place twice a day. One month is a course of treatment ． In every course of treatment ， obsrve respectively the two group members ’ areas of skin lesions and colour which appear before and after the treatment，record the cardinal symptoms and minor symptoms，and record the adverse reactions at any time．Finaly，make statistical analysis to the two observated group and then evaluate the treating effect of The Treating Group． Results: In The Treating Group，three patientsare cured，eigth have tangible effects， thirteen are improved，an