肠黏膜生物屏障与肠易激综合征的治疗-内科学(消化)专业论文.docxVIP

重庆医科 重庆医科大学硕士研究生学位论文 万方数据 万方数据 英汉缩略语名词对照 英文缩写 GI 英文全称 gastrointestinal 中文全称 胃肠道 TJ tight junction 紧密连接 AJC apical junctional complex 顶部连接复合物 TLRs toll-like receptors Toll 样受体 NODs nucleotide-binding oligomerization 核苷酸结合寡聚化 domain-like receptors 结构域 IBS Irritable bowel syndrome 肠易激综合征 IBS-C IBS with constipation 便秘型 IBS IBS-D IBS with diarrhea 腹泻型 IBS IBS-M Mixed IBS 混合型 IBS IBS-U Unsubtyped IBS 未定型 IBS HRQOLS health-related quality of life scores 健康相关生活质量 指数 TCAs tricyclic antidepressants 三环类抗抑郁药 SSRIs selective serotonin reuptake 选择性 5-羟色胺再 SCFAs inhibitors short-chain fatty acids 摄取抑制剂 短链脂肪酸 NF-κB nuclear factor-kappaB 核因子κB IBD inflammatory bowel disease 炎症性肠病 PI-IBS post-infectious IBS 感染后 IBS SIBO small intestinal bacterial 小肠细菌过度生长 overgrowth PPIs proton pump inhibitors 质子泵抑制剂 LBHT lactulose breath hydrogen test 乳果糖氢呼气试验 CIC chronic idiopathic constipation 功能性便秘 NSPs nonstarch polysaccharides 非淀粉多糖 1 CDI clostridium difficile infection 艰难梭状芽孢杆菌 FMT fecal microbiota transplantation 感染 粪菌移植 2 肠黏膜生物屏障与肠易激综合征的治疗 摘要 肠黏膜生物屏障作为肠黏膜屏障的一员，与胃肠道的机械屏障及 免疫功能关系密切。肠道菌群失调、小肠细菌过度生长均可破坏肠黏 膜生物屏障功能，参与肠易激综合征的发生。给予益生菌调整肠道菌 群失调、抗生素抑制小肠细菌过度生长可修缮肠黏膜生物屏障，从而 可改善肠易激综合征临床症状。 关键词：肠黏膜生物屏障，肠易激综合征，益生菌 3 INTESTINAL MUCOSAL BIOLOGICAL BARRIER AND THE TREATMENT OF IRRITABALE BOWEL SYNDROME ABSTRACT The intestinal mucosal biological barrier is a member of the intestinal mucosal barrier systeme and it plays a critical role in the normal physiologic and immunologic functions of the gastrointestinal(GI).Dysbiosis and small intestinal bacterial overgrowth can destroy the integrity of intestinal mucosal biological barrier,and the alterations in GI microbiota can lead to irritable bowel syndrome.Probiotics which adjust intestinal flora,and antibiotics, which inhibit intestinal bacterial overgrowth, can repair the damaged intestinal mucosal biological barrier, so as to achieve the purpose of improving the symptoms of irritable bowel syndrome. Key words ： intestinal mucosal biological barrier,irritable b