莪达夏对大鼠心肌缺血再灌注损伤的保护作用研究-中西医结合临床专业论文.docxVIP

Abstract Experimental study on Oxytropis falcate Bunge on Myocardial Ischemia—reperfusion Injury in Rats In recent years, with social progress and development, cardiovascular disease is becoming a serious threat to human health, one of the top causes of death, and presents a growing trend of younger, studies show that: the next few years, cardiovascular disease The incidence rate will rise substantially. Myocardial ischemia-reperfusion injury as cardiovascular disease common disease, more and more concern. Hypoxia (blood) can cause a series of physiological compensatory response and pathological changes, the use of some anti-hypoxia drugs to improve the bodys oxygen supply and energy state of the body to improve the quality of life and activity of the body at high altitude has a very significance. Therefore, the antioxidant effect of myocardial ischemia-reperfusion injury to become a research focus, looking for natural, effective, safe, high-quality, long-term use, protection of myocardial ischemia-reperfusion injury in Tibetan medicine herbs is now the field of medicine one of the direction of research and development. Objective: To study Tibetan medicine Oxytropis falcate Bunge aqueous extract on myocardial ischemia-reperfusion injury in rats myocardial ischemia reperfusion period ECG ST-segment changes and LDH, CK, SOD, GSH-Px, MDA level, clear anti-oxidation mechanism of myocardial ischemia-reperfusion injury antioxidant Tibetan medicine developed to provide the theoretical and experimental basis. Methods: 120 of 8-week-old SD rats (150 ± 20) g weight, male and female, provided by the Experimental Animal Center of Lanzhou Medical College, animal license number: SCXK (Gan) 2012-0002. Number of male and female rats using random number table assigned to 6 groups (n=20), male and female, respectively: sham operation group (serum as normal control group), ischemia - reperfusion model group (model group) Curcuma Da Xia alcohol extract high-dose group (high dose group