从血压调节系列蛋白基因筛选有氧运动能力分子标记及功能研究-体育学专业论文.docx

The polymorphisms of AGT rs2148582, REN rs5707, REN r ACE rs4344, ACE rs4343, AGTR1 rs5182, AGTR2 rs1403543 are significant assocaiton with lung function. The polymorphisms ofAGTrs2148582,rs5051， RENr ACErs4344, ACErs4363, ACE rs4343, NR3C2rs6810951 and r GNASrs7121are significant assocaiton with cardiovascular function. REN haplotypes, CYP11B1 and CYP11B21-3 haplotype, ADD1 haplotypeare significant assocaiton with lung function. REN haplotype, ACEhaplotype, CYP11B1-CYP11B2（1-2 and 1-3）haplotypes are significant assocaiton with cardiovascular function. Conclusion AGTR1 gene rs5182 could be a candidategenetic mark of selectione lite endurance athletes in Han Population from Northern China, but this polymorphism does not affect aerobic capacity through changing AT1R mRNA levels. rs2148582、rs5707、rrs4344、rs4343、rs5182 、rs4363、 rs6810951、rrs7121、rs1403543，and REN、ACE、CYP11B1-CYP11B2、 ADD1 haplotypes could be candidate molecular markers to predict lung and cardiovascular function of endurance athletes in Han Population from northern China. Key Words ： Renin-Angiotensin-Aldosterone System, Aerobic capacity, polymorphism, Molecular Marker 论文随机验证编号：BT6183622423677 VI 目录 HYPERLINK \l _bookmark0 1 前言............................................... - 3 - HYPERLINK \l _bookmark1 2 文献综述........................................... - 5 - HYPERLINK \l _bookmark2 2.1 RAAS 及 ADD1 等血压调节蛋白研究进展 ......................- 5 - HYPERLINK \l _bookmark3 2.1.1 RAAS 概况 .................................................. - 5 - HYPERLINK \l _bookmark4 2.1.2 RAAS 中的重要底物和反应酶 .................................. - 7 - HYPERLINK \l _bookmark5 2.1.3 RAAS 的作用机制和信号通路 .................................. - 9 - HYPERLINK \l _bookmark6 2.1.4 α内收蛋白等血压调节蛋白.................................. - 13 - HYPERLINK \l _bookmark7 2.1.5 血压与运动 ............................................... - 14 - HYPERLINK \l _bookmark8 2.2 血压调节系列蛋白基因多态性研究进展 .....................- 15 -