生物化学ii（苏维恒）核酸的降解与核苷酸代谢教学材料.ppt

Tetrahydrofolate (THF) Methylation of dUMP catalyzed by thymidylate synthase Cofactor: N5,N10-methylene THF（甲叉四氢叶酸）oxidized to dihydrofolate THF Regeneration: DHF + NADPH + H+ ? THF + NADP+ (enzyme: dihydrofolate reductase) THF + Serine ? N5,N10-methylene-THF + Glycine (enzyme: serine hydroxymethyl transferase) dUMP dTMP NADPH + H+ NADP+ SERINE GLYCINE REGENERATION OF N5,N10 METHYLENETETRAHYDROFOLATE DHF N5,N10 – METHYLENE-THF THF dihydrofolate reductase serine hydroxymethyl transferase thymidylate synthase Anti-Folate Drugs Cancer cells consume dTMP quickly for DNA rep