生化2018 c15 dna damage and repair教学材料.pptVIP

Direct repair of pyrimidine dimer * Direct repair of alkylated base * Direct repair of depurination site Rebuild of glycosyl bond catalyzed by DNA purine insertion enzyme,leading to the purine direct insertion, which has very high specificity Direct repair of single strand breakage Rebuild of phosphodiester bond by DNA ligase * 2. Excision repair of DNA damage Base excision repair Nucleotide excision repair * Base excision repair ① to recognize and to hydrolyze：the impaired base is recognized and hydrolyzed by DNA glycosylase specifically, leading to the abasic site ② to cut off：the phosph