礞石滚痰丸合并传统抗精神病药物治疗精神分裂症临床对照的研究.docVIP

礞石滚痰丸合并传统抗精神病药物治疗精神分裂症临床对照的研究 　　【摘要】目的观察礞石滚痰丸合并传统抗精神病药物治疗精神分裂症的疗效以及不良反应。方法将96例精神分裂症患者随机分为两组,对照组用传统抗精神分裂症西药治疗。治疗组在西药治疗的基础上加服礞石滚痰丸,治疗6周评定疗效,用阳性与阴性症状量表(PANSS)、简明精神病量表(BPRS)因子评分和副反应量表(TESS)评定疗效和不良反应。结果治疗组显效率为69.00%,对照组为43.48%(P0.01);治疗组不良反应少于对照组(P0.05或P0.01)。结论中成药礞石滚痰丸对精神分裂症有治疗作用。中西医结合治疗精神分裂症疗效优于单纯西药治疗,其毒副反应轻于单纯西药治疗。 　　【关键词】精神分裂中西医结合疗法礞石滚痰丸 　　中国图分类号:R749.3文献标识码:A 文章编号:1005-0515(2010)08-011-02 　　 A Clinical Control Study of Mengshi Guntan Wan Cembined With Western Medicine for Schizophrenia ZHU QiangSUN YuexiaYULianyu 　　 Zibo Mental Hospital, Zibo 255100,China 　　【Abstrac】objectiveTo study the therapentic effect of Mengshi Guntan Wan for schizophrenia. MethodsTotallg 96 cases of schizophrenia were rondomly divided into 2 groups. The control group was treated by western medicine, while Mengshi Cuntan wan was added in the treatment group. Positive and Negative symptoms Scale(DANSS), Brief psychiatric Rating Scale(BPRS)and Treatment Emergent symptom scale (TESS) were used to identity the therapentic and adverse effect after 6 weeks treatment. ResultsThe excellence rate in treatment graup was 64.00% ,while 43.48% in confrol group (P0.01) ,The adverse effect in treatment group was less than that in control group(P0.05orP0.01).CondusionMengshi Cuntan wan has therapentic effect for schizophvenia. The therapentic effect of integrated Chinese and western medicine tveatment is superor fo western medicine with less adverse effect and shorter treafment course. 　　【Key words】SchizophreniaIntegrated therapy of Chinese and Western medicineMengshi Cuntan Wan. 　　 　　 精神分裂症是一组原因未明的精神病,是以感知、思维、情感、行为等多方面障碍和精神活动不协调为主要特征的一种最常见的精神病,多见于青壮年,复发率高,给社会和家庭带来严重的危害,目前精神分裂症多采用传统抗精神病药物治疗,西药治疗多有较严重的副反应及脏器损害。本病中医辩证多为气郁,顽痰蒙蔽心窍,所致神志错乱,属“癫狂”范畴。二者在症状上虽有差异,但在病理变化上仍有所相关。礞石滚痰丸具有逐痰降火,泻火通便作用。我们应用礞石滚痰丸合并传统抗精神病药物是否可以增强传统药物治疗精神分裂症的疗效以及减轻传统药物所致口干,便秘等不良反应。 　　1..临床资料 　　 按照中国精神疾病分类与诊断标准(CCMD-3)[1]选择精神分裂症患者96例,按随机化平行试验设计方法,分为治疗组与对照组。其中治疗组50例,男29例,女21例,年龄16-64岁,平均(30.66±10.62)岁,病程1个月-30年,平均(6.65±5.43)年,对照组46例,男24例