更昔洛韦联合免疫球蛋白治疗小儿急性病毒性脑炎的的疗效观察.docVIP

更昔洛韦联合免疫球蛋白治疗小儿急性病毒性脑炎的的疗效观察 　　【摘要】目的：探讨更昔洛韦联合免疫球蛋白(IVIG)在治疗小儿急性病毒性脑炎(AVE)中的作用。方法：对82例小儿AVE患者，按入院先后顺序随机分为观察组和对照组，每组41例。对照组给予更昔洛韦治疗，而观察组给予更昔洛韦联合IVIG治疗，对两组的临床疗效指标进行观察。结果：观察组在疗效及病程方面明显优于对照组，未见明显不良反应，组间比较差异有统计学意义(P0.05)。结论：更昔洛韦联合IVIG是治疗急性病毒性脑炎的一种安全有效的措施，优于单用更昔洛韦治疗，具有重要价值，值得临床推广。 　　【关键词】免疫球蛋白；更昔洛韦；小儿；急性病毒性脑炎 　　 　　Clinical Efficacy of Ganciclovir Combined with Immunoglobulin in Treatment of Children with Acute Viral Encephalitis/LUO Li-hua.// Medical Innovation of China，2012，9(11):039-040 　　【Abstract】Objective：To explore the clinical efficacy of ganciclovir combined with immunoglobulin (IVIG) in treatment of children with acute viral encephalitis.Methods:According to the admission，82 children with acute viral encephalitis were randomly divided into observation and control group(n=41).The control group was given ganciclovir treatment，while the experimental group given ganciclovir IVIG therapy. On two groups of clinical effectiveness indexes were observed.Results:Efficacy and duration of the observation group is better than the control group.the difference was significant between groups (P0.05).The two groups showed no significant adverse effects.Conclusion:Ganciclovir combined with IVIG is a safe and effective measures to better than ganciclovir in treatment of children with acute viral encephalitis，have important clinical value and is worthy of promotion 　　【Key words】Immunoglobulin；Ganciclovir ；Children；Acute viral encephalitis 　　First-author’s address:Bazhou District Maternal and Child Health Hospital， Bazhong 636000，China 　　doi：10.3969/j.issn.1674-4985.2012.11.022 　　 　　急性病毒性脑炎(acute viral encephalitis，AVE)是儿科比较常见的由病毒感染引起的与机体免疫功能有关的中枢神经系统疾病，病情轻重不等，危重者可导致患儿死亡及后遗症。笔者所在医院儿科采用更昔洛韦联合联合人血免疫球蛋白(intravenous Immunoglobulins，IVIG)治疗小儿急性病毒性脑炎，效果较好，现报道如下。 　　1资料与方法 　　1.1一般资料选择2008年1月-2011年12月笔者所在医院儿科AVE患者82例，男43例，女37例，年龄0.5~13岁。患者均有不同程度的意识障碍、高热、抽搐、肢体运动障碍，伴有智力损害及精神异常表现，均符合《儿科学》的病毒性脑炎诊断标准[1]。按入院先后顺序随机分为观察与对照组，每组41例。两组的性别、年龄、临床症状和体征、病情轻重、入院时病程等比较差异均无统计学意义，具可比性(P0.05)。 　　1.