钯催化的脱羧基烷基化反应PalladiumCatalyzedDecarboxylative.PDF

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 12 期, 2181～2187 Chinese Journal of Organic Chemistry No. 12, 2181～2187 ·学术动态· 钯催化的脱羧基烷基化反应 周其忠*,a 张 斌 a,b 陈 丹 a 陈仁尔 a 蒋华江*,a (a 台州学院化学系 台州 317000) (b 浙江工业大学药学院 杭州 310014) 摘要 钯催化的脱羧基烷基化反应是构建碳碳键特别是手性碳的有效手段, 其催化活性高, 反应条件温和, 对映选择 性好. 近年来该领域取得了长足的进步. 介绍了 5 年来钯催化的脱羧基烷基化反应, 主要是钯催化的对映选择性 Tsuji 反应及其在天然产物合成中的应用. 关键词 钯催化; 脱羧基; 烯丙基化; 苄基化; 对映选择性 Palladium Catalyzed Decarboxylative Alkylation Zhou, Qizhong*,a Zhang, Bina,b Chen, Dana Chen, Renera Jiang, Huajiang*,a a ( Department of Chemistry, Taizhou University, Taizhou 317000) (b College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014) Abstract Palladium catalyzed decarboxylative alkylation is an effective way to construct carbon-carbon bond especially chiral center with high catalytic activity, mild reaction conditions and good enantioselectivi- ty. In recent years, great achievements have been obtained in this field. This paper summarizes palladium catalyzed decarboxylative alkylation and mainly focuses on enantioselective Tsuji reaction and its utility in natural product synthesis in recent 5 years. Keywords palladium catalysis; decarboxylation; allylation; benzylation; enantioseletivity C—C 键的构建是有机合成领域研究的重要内容, O O Pd0 O 近 30 年来, 通过脱羧基烷基化构建 C—C 键是其中的 O R R 种重要的