过敏性紫癜患儿血浆XIII因子检测的探讨.docVIP

过敏性紫癜患儿血浆XIII因子检测的探讨 　　【摘要】目的：探讨过敏性紫癜患儿血浆中XIII因子活性变化在临床诊治中的意义。方法：选择35例过敏性紫癜患儿，男16例，女19例，年龄分布在3-14岁，平均8.5岁。采用单碘醋酸耐量试验和XIII因子定性试验，检测35例过敏性紫癜（AP）患儿血浆中XIII因子水平。结果：35例过敏性紫癜患儿中，有11例胃肠型过敏性紫癜患儿XIII因子水平明显低于对照组，两组资料比较有显著性差异（t=12.303, P值0.05）。而24例非胃肠型过敏性紫癜患儿与对照组血浆XIII因子水平差别无显著性意义（t=1.921, P值＞0.05）。结论：XIII因子水平检测对儿童胃肠型过敏性紫癜患儿的诊治具有一定的临床意义。 　　【关键词】XIII因子 紫癜 过敏性 　　Discussion of the examination of XIII factor in blood plasma for children sufferring allergic purpura 　　Yang JianChen XiaoDanWen XiaoMeiChen XingqunCai WangWei 　　【Abstract】Purpose: Discussing the meaning of active change in XIII factor in blood plasma for children of allergic purpura in diagnosis and medical treatment. Method: Selecting 35 allergic purpura children, male 12, female 18, age ranges from 3 to 14 years old, the average is 8.5 years old. Adopting MIA Tolerance Test and XIII factor Qualitative Test, examining 35 allergic purpura(AP) children with the activity of XIII factor in their blood plasma. Result: The activity of XIII factor of 11 children of gastrointestinal type among 35 allergic purpura children, shows obviously lower level than that of the control group and that of the children of the non-gastrointestinal type. The two compared group has a remarkable difference（t=12.303, P0.05）. However, comparing 24 allergic purpura children of non-gastrointestinal type with the control group in XIII factor has little meaning. The two compared group has little difference（t=1.921, P＞0.05）. Conclusion: The examination of XIII factor activity has certain clinical meaning in allergic purpura children of gastrointestinal type. 　　【Key words】XIII factor allergic purpura 　　 　　过敏性紫癜(allergic purpura AP) 又称享诺-许兰紫癜（Henoch-schonlein purpura HSP）是一种常见的血管变态反应性出血性疾病，或称出血性毛细血管中毒症［1］。由于机体对某些致敏物质发生变态反应，引起广泛的小血管炎，使小动脉和毛细血管血浆外渗至皮下、粘膜下、浆膜下，临床除瘀点、瘀斑外，还有腹部消化道症状，肾脏损伤等全身症状。 　　实验室检测PT、APTT、血小板计数和出血时间均正常。血常规检查、骨髓象检查基本正常。本文采用单碘醋酸耐量试验和XIII因子定性试验，对临床确诊的35例过敏性紫癜患儿按有无腹痛等腹部症状，分成胃肠型和非胃肠型两组，分别在发病急性期进行XIII因子水平检测及治疗腹痛症状缓解后复查XIII因子，现报道如下。