超声评价吡格列酮对2型糖尿病患者早期颈动脉内中膜变化的研究.docVIP

超声评价吡格列酮对2型糖尿病患者早期颈动脉内中膜变化的研究 　　[摘要] 目的 探讨吡格列酮对2型糖尿病患者颈动脉内-中膜厚度（IMT）的影响。 方法 将198例2型糖尿病（T2DM）患者分为实验组（100例）与对照组（98例），均接受常规降糖治疗。实验组加服吡格列酮，疗程为6个月。治疗前后用彩超检测IMT，比较两组IMT变化及IMT异常率。 结果 实验组治疗后PBG、HbA1c、TG较对照组低，HDL较对照组高，组间差异有统计学意义（P0.05）；治疗后实验组颈动脉IMT值小于对照组，差异有统计学意义（P0.05）；两组治疗后IMT异常率比较差异有统计学意义（P0.05）。 结论 吡格列酮可以降低2型糖尿病患者IMT水平，有助于抑制糖尿病患者早期动脉粥样硬化的发生和发展。 　　[关键词] 2型糖尿病；吡格列酮；颈动脉内膜-中膜厚度 　　[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701（2015）09-0097-03 　　Study on the effects of pioglitazone hydrochloride to carotid intima-media thickness changes of the type 2 diabetes patients 　　TAN Jielin WEI Xi 　　Department of Ultrasound， the Peoples Hospital of Liuzhou City in Guangxi Zhuang Autonomous Region， Liuzhou 545006， China 　　[Abstract] Objective To investigate the effects of pioglitazone hydrochloride tablets to carotid intima-media thickness for the patients with type 2 diabetes. Methods All 198 cases with type 2 diabetes （T2DM） were divided into the experimental group（n=100） and the control group（n=98）， both groups were given the conventional antidiabetic therapy. The experimental group was given pioglitazone hydrochloride tablets， the treatment was six months. IMT before and after treatment was detected with ultrasound， IMT changes and IMT abnormal rate of both groups were compared. Results PBG， HbA1c， TG of the experimental group were lower than those of control group， HDL was higher than the control group， there was significant difference between two groups（P0.05）. IMT values after the treatment of the experimental group was lower than the control group， there was significant difference between two groups（P0.05）. There was significant difference in IMT abnormal rate between two groups（P0.05）. Conclusion Pioglitazone hydrochloride tablets can decrease IMT of the patients with type 2 diabetes mellitus by reducing insulin resistance and anti-inflammatory effects， inhibition early atherosclerosis development and progression of the patients. 　　[Key words] Type 2 diabetes； Pioglitazone；