肝动脉化疗栓塞治疗原发性肝癌合并糖尿病相关预后的探讨.docVIP

肝动脉化疗栓塞治疗原发性肝癌合并糖尿病相关预后的探讨 　　[摘要] 目的 分析肝动脉化疗栓塞治疗原发性肝癌合并糖尿病的临床效果，并对其预后影响因素进行探究。 方法 选择该院自2014年5月―2017年6月期间收治的原发性肝癌合并糖尿病患者22例，将其作为A组，随后选取同期入院的原发性肝癌患者22例，将其作为B组，所有患者均接受肝动脉化疗栓塞治疗，最后对其临床效果和预后情况进行总结。结果 经回顾性分析后可知，比对A组和B组患者的总生存时间，组间数据结果经证实后差异无统计学意义（P0.05）。比对A组和B组患者的肝外转移率，组间数据结果经证实后差异有统计学意义（P0.05）。另外，原发性肝癌合并糖尿病患者的预后影响因素与空腹血糖参数、肿瘤大小和ECOG评分存在相关性，同时与BCLC分期和门脉癌栓有着直接关系。结论 原发性肝癌合并糖尿病的独立预后因素为空腹血糖参数，其可以为临床提供有力依据。 　　[关键词] 肝动脉化疗栓塞；原发性肝癌合并糖尿病；预后；影响 　　[中图分类号] R735.7 [文献标识码] A [文章编号] 1672-4062（2018）01（a）-0028-02 　　[Abstract] Objective To analyze the clinical effect and prognosis of transcatheter arterial chemoembolization in treatment of primary liver cancer combined with diabetes. Methods 22 cases of patients with primary liver cancer and diabetes admitted and treated in our hospital from May 2014 to June 2017 were selected the group A， while 22 cases of patients with primary liver cancer admitted and treated at the same period were selected as the group B， and all patients were treated with transcatheter arterial chemoembolization， finally， the clinical effect and prognosis were summarized. Results The retrospective analysis showed that the difference in the total survival time between the two groups was not statistically significant（P0.05）， and the difference in the extrahepatic metastasis rate between the two groups was statistically significant（P0.05）， besides， the prognosis influence factors of patients with primary liver cancer and diabetes were correlated with the fasting blood glucose parameters， size of tumors and ECOG score， and were directly correlated with the BCLC staging and portal vein tumor thrombus. Conclusion The independent prognosis factor of primary liver cancer and diabetes is the fasting blood glucose parameter， which can provide powerful basis for clinic. 　　[Key words] Transcatheter arterial chemoembolization； Primary liver cancer and diabetes； Prognosis； Effect 　　在恶性肿瘤疾病中肝癌较为常见，其中原发性肝癌的比例约80%[1]。近年来，人们生活水平的不断提升，生活方式的不断转变，致使糖尿病的发生率呈逐年上升趋势发展。据相关资料显示，原发性肝癌和糖尿