阿尔茨海默病临床诊治的研究.docVIP

阿尔茨海默病临床诊治的研究 　　[摘要] 目的 探讨阿尔茨海默病的临床诊治。方法 选取该院2010年1月―2012年1月间收治的阿尔茨海默病患者31例为观察组，回顾性分析其临床资料；选取同期在该院进行健康体检的老年人31例为对照组，用MRI检测两组研究对象的侧脑室体积，对比2010―2011年侧脑室变化情况。结果 65岁以上的患者较65岁以下的患者比例显著升高（P0.01），性别之间无统计学差异；临床主要表现为记忆力下降；简易智能量表评分均低于23分，其中重度痴呆占多数；超1/4的患者具有家族阳性史；2年内观察组患者左侧、右侧和双侧侧脑室体积明显大于正常组（P0.01）；观察组患者侧脑室体积随时间的推移呈明显递增趋势。结论 该病的早期诊治仍为临床工作的重点，基因诊断和治疗可能具有较好的效果，各侧侧脑室体积动态变化情况可能是阿尔茨海默病患者的特征性影像学表现之一，可用于临床判断疾病的严重程度。 　　[关键词] 阿尔茨海默病；临床表现；诊断；治疗 　　[中图分类号] R749.16 [文献标识码] A [文章编号] 1674-0742（2014）04（b）-0006-02 　　[Abstract] Objective To explore the clinical diagnosis and treatment of Alzheimers disease. Methods 31 cases of patients with Alzheimers disease admitted in our hospital from January， 2010 to January， 2012 were selected as the observation group， and the clinical data of them were analyzed retrospectively. And 31 cases of elderly people underwent healthy examination in our hospital during the same period were selected as the control group. MRI was used to detect lateral ventricular volume of the two groups of patients， and the lateral ventricle changes between 2010 and 2011 were compared. Results The proportion of patients over 65 years with the disease was significantly higher than that of the patients below the age of 65 （P0.01）， but there was no statistically significant difference between that of male patients and female patients； the main clinical manifestations were memory deterioration； MMSE scores were lower than 23 points， severe dementia were in the majority； over 1/4 patients with positive family history. During the two years， the left ventricular volume， the right ventricular volume and bilateral ventricle volume of the patients in the observation group were obviously bigger than those of the patients in the control group （P0.01）； the lateral ventricle volume of the patients in the observation group showed an increasing trend over time. Conclusion Early diagnosis and treatment of this disease is still the focus of clinical work. Gene diagnosis and gene therapy may h