不同剂量腺苷蛋氨酸治疗病毒性肝炎疗效对比剖析.docVIP

不同剂量腺苷蛋氨酸治疗病毒性肝炎疗效对比剖析 　　[摘要]目的 对比分析不同剂量腺苷蛋氨酸治疗病毒性肝炎的疗效。方法 选取该院2013年7月―2014年7月期间收治的90例病毒性肝炎患者作为研究对象，随机分为A组和B组，每组各45例，A组45例患者予以1 000 mg/d的腺苷蛋氨酸进行治疗，B组45例患者予以2 000 mg/d腺苷蛋氨酸进行治疗，对于两组中出现的重症患者，均辅以其它护肝等对症治疗，对比观察不同剂量腺苷蛋氨酸治疗病毒性肝炎的的临床效果和不良反应。结果 治疗后A组和B组ALT、AST、Alb、TBil、TBA、ALP、GGT、PT指标均有所改善，B组ALT、AST、TBil下降程度与A组比较，差异有统计学意义（P0.05）。两组患者未出现不良反应。结论 大剂量的腺苷蛋氨酸治疗病毒性肝炎比小剂量效果更明显，且安全性较高。 　　[关键词] 腺苷蛋氨酸；病毒性；肝炎；剂量 　　[中图分类号] R714 [文献标识码] A [文章编号] 1674-0742（2015）10（b）-0021-03 　　Comparison of the Therapeutic Effect of Different Doses of Ademetionine on Viral Hhepatitis 　　YU Feng-qin 　　Department of Liver Diseases， Huaian No 4 Peoples Hospital， Huaian， Jiangsu Province， 223002 China 　　[Abstract] Objective To observe and compare the efficacy of different doses of ademetionine for the treatment of viral hepatitis. Methods Ninety cases with viral hepatitis admitted in our hospital from July 2013 to July 2014 were selected as the subjects and randomly divided into group A and group B with 45 cases in each. Patients in group A were treated by 1 000 mg ademetionine per day， and those in group B were treated by 2 000 mg ademetionine per day. The severe patients in the two groups were given protection of liver and other symptomatic treatment additionally. And the clinical effect and incidence of adverse reactions of the two groups were observed and compared. Results After treatment， the values of ALT， AST， Alb， TBil， TBA， ALP， GGT and PT improved in both groups. The differences in the reduction of the values of ALT， AST and TBil between group A and group B were statistically significant， P0.05. No adverse reactions occurred in both groups. Conclusion Large dose of ademetionine has more significant effect on viral hepatitis than small dose of ademetionine with higher safety. 　　[Key words] Ademetionine； Viral； Hepatitis； Dose 　　肝炎通常是由多种致病因素如病毒、细菌、寄生虫、化学毒物、药物、酒精、自身免疫因素等使肝脏细胞受到破坏，肝功能受损，引起的一系列不适症状。由于引发肝炎的病因不同，虽有类似的临床表现，但是在病原学、损伤机制、预后以及诊治方面有明显的不同。病毒性肝炎是肝炎的一种，由病毒引起，如不及时治疗，严重影响患者的生存质量。目前临床上将腺苷蛋氨酸