我院Ⅰ类切口手术围手术期预防用抗菌药物干预效果剖析.docVIP

我院Ⅰ类切口手术围手术期预防用抗菌药物干预效果剖析 　　摘要：目的 探讨实施干预前后我院Ⅰ类切口手术围术期预防性使用抗菌药物的合理性。方法 选取2012年1月~12月实施干预前我院Ⅰ类切口手术患者的病历资料210例和2013年1月~12月实施干预措施后我院Ⅰ类切口手术患者的病历资料224例，比较两组抗菌药物使用的合理性。结果 实施干预后，抗菌药物的使用率由干预前的100%降至60.3%，无指征预防用药率由77.1%下降至29.9%，前后差异均具有统计学意义（P0.05）；术前和术后用药不合理率分别由干预前的69.0%和73.8%下降至8.0%和9.8%，抗菌药物的平均费用由干预前的（1048.3±87.5）元降至（210.2±43.7）元，前后比较差异均具有统计学意义（P0.05）。结论 通过采取有效的干预措施，可显著提高我院抗菌药物使用的合理率，降低抗菌药物的费用，对促进临床安全、有效、合理应用抗菌药物具有良好效果。 　　关键词：Ⅰ类切口手术；围手术期；抗菌药物；干预措施 　　The Analysis of Intervening Effect of Antibacterial Agents Using During Perioperative Period for ClassⅠOperation 　　in Our Hospital 　　QIU Zhi-qing,XIE Li-ming,XIE Hua-jin,ZENG Rong-shi 　　(Department of Pharmaceutical,The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001,Guangdong,China) 　　Abstract：ObjectiveTo observe the intervening effect of antibacterial agents using during perioperative period for classⅠoperation in our hospital. MethodsThe clinical data of 210 patients in our hospital from Jan to Dec 2012 as pre-intervention and 224 patients from Jan to Dec 2013 as after intervention was selected. The rationality of antibacterial agents using were analyzed. ResultsAfter intervention, the usage of antibacterial agents fell to 100% from 60.3%. No indications prevention rate fell to 29.9% from 77.1% respectively, the differences were all statistically significant (P0.05). The preoperative and postoperative unreasonable rate fell to 8.0% and 9.8% from 69.0% and 73.8%. The average costs of antimicrobial drugs fell to (210.2±43.7) from (1048.3±87.5), the differences were all statistically significant (P0.05). ConclusionThrough the effective intervention measures, can significantly improve the hospital antimicrobial drug usage, reduce the costs of the antibacterial drugs, promote safe and effective rational clinical application of antimicrobial agents. 　　Key words：ClassⅠoperation,;Perioperative;Antimicrobial;Intervention围手术期合理预防性使用抗菌药物可有效降低外科手术部位切口感染（SSI）的发生率，从而保证患者获得最佳的手术治疗效果。但是，如果抗菌药物使用不当或者滥用，很可能导致真菌感染和耐药