窄谱中波紫外线联合卡泊三醇治疗稳定期白癜风疗效剖析.docVIP

窄谱中波紫外线联合卡泊三醇治疗稳定期白癜风疗效剖析 　　[摘要]目的：观察分析窄谱中波紫外线联合卡泊三醇治疗稳定期白癜风的疗效及不良反应。方法：采取随机数字表法，将符合要求的129例患者分为卡泊三醇组、窄谱中波紫外线组和窄谱中波紫外线联合卡泊三醇组，每组43例。窄谱中波紫外线组：采用窄谱中波紫外线光疗仪照射，波长311nm，初始剂量为0.3J/cm2，之后每次递增10%，2次/周；卡泊三醇组：使用卡泊三醇外擦，每天1次；窄谱中波紫外线联合卡泊三醇组：在每天涂抹卡泊三醇的基础上，进行窄谱中波紫外线照射。疗程为24周，三组患者在治疗前、后测定皮损面积，分别对不良反应进行观察和记录。结果：窄谱中波紫外线联合卡泊三醇组与卡泊三醇组及窄谱中波紫外线组临床疗效比较，差异有统计学意义（χ2=6.76，P0.05）。结论：窄谱中波紫外线联合卡泊三醇治疗稳定期白癜风是一种安全、有效的治疗方法，值得临床推广。 　　[关键词]窄谱中波紫外线；卡泊三醇；稳定期白癜风；疗效 　　[中图分类号]R758.4+1 [文献标志码]A [文章编号]1008-6455（2015）21-0044-03 　　Abstract： Objective To observe the curative effect and adverse reaction of NB-UVB combined with calcipotriolt in the treatment of stable vitiligo. Methods We took a random number table method on the 129 patients.They were divided into calcipotriol group，NB- UVB group and NB-UVB combined with calcipotriol group，43 cases in each group.NB-UVB group were treated with NB-UVB phototherapy with ultraviolet irradiation，Wavelength 311nm.The initial dose set to 0.3 J/cm2，after each increase of 10%，2/W；calcipotriol group were used calcipotriol outside the rub，1 times a day；NB-UVB combined with calcipotriol group in every day smearing calcipotriol，with narrow spectrum UVB irradiation；treatment for 24 weeks，three groups in treatment were measured before and after the lesion area，respectively of adverse reactions were observed and recorded. Results NB-UV B combined calcipotriol group and calcipotriol group and NB-UVB group，the difference in clinical efficacy was statistical significance（χ2=6.76，P0.05）. Conclusion NB-UVB phototherapy combined with calcipotriol in the treatment of stable vitiligo is a safe and effective method for the treatment of，it is worth clinical promotion 　　Key words：NB-UVB；calcipotriol；stable vitiligo；curative effect 　　白癜风是一种以表皮黑素细胞消亡形成局限性的色度脱失斑为特点的疾病，可在机体任何部位发病，可多发，易诊难治，发病多呈进展性，影响患者外在美观，严重影响其生活质量。白癜风目前临床主要治疗手段包括药物治疗、物理治疗和手术治疗等[1]。有研究认为，稳定期白癜风患者应用中波窄谱紫外线疗法，效果明确[2]。为探讨更为有效、可靠的治疗方法，本研究针对稳定期白癜风患者采取窄谱中波紫外线联合卡泊三醇的治疗方法，取得了满意疗效，现报道如下。 　　1 资料和方法 　　1.1 一般资料 　　129例稳定期白癜风患者均来自