甘精胰岛素联合那格列奈强化治疗初发2型糖尿病疗效剖析.docVIP

甘精胰岛素联合那格列奈强化治疗初发2型糖尿病疗效剖析 　　[摘要] 目的 针对初发2型糖尿病患者实施甘精胰岛素联合那格列奈强化治疗，进一步评价联合用药的疗效。方法 该次入选的初发2型糖尿病患者92例，纳入时间跨度为2015年1月―2016年1月，按?S机抽样法分成两组，每组46例；对照组患者单用那格列奈进行医治，观察组患者则实施甘精胰岛素联合那格列奈强化治疗，对两组临床治疗效果进行比较评价。结果 在空腹血糖（FBG）、餐后2 h血糖（2 hPBG）以及糖化血红蛋白（HbA1c）3项指标水平，治疗前两组比较差异无统计学意义（P0.05）；经积极治疗后，观察组改善效果均显著优于对照组（P0.05）；经积极治疗后，观察组改善效果均明显优于对照组（P0.05）。结论 对于初发2型糖尿病患者，给予甘精胰岛素联合那格列奈强化治疗具备显著疗效，可改善患者血糖水平，进一步改善患者生活质量；因此值得采纳及使用。 　　[关键词] 甘精胰岛素；那格列奈；强化治疗；初发2型糖尿病；疗效 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）11（b）-0003-02 　　[Abstract] Objective To further evaluate the curative effect of insulin glargine combined with nateglinide in intensive treatment of initial type 2 diabetes. Methods 92 cases of initial type 2 diabetes patients from January 2015 to January 2016 were selected and randomly divided into two groups with 46 cases in each， the control group were treated with single nateglinide， while the observation group were treated with insulin glargine combined with nateglinide， and the clinical treatment effect was compared and evaluated. Results There were no obvious differences in the FBG， 2 hPBG and HbA1c levels between the two groups before treatment（P0.05）， after the positive treatment， the improvement effect in the observation group was obviously better than that in the control group（P0.05）， after the positive treatment， the improvement effect in the observation group was obviously better than that in the control group（P0.05）. Conclusion The curative effect of insulin glargine combined with nateglinide in intensive treatment of initial type 2 diabetes is obvious， which can improve the blood glucose level and further improve the quality of life， therefore， it is worth recommendation and application. 　　[Key words] Insulin glargine； Nateglinide； Intensive treatment； Initial type 2 diabetes； Curative effect 　　2型糖尿病是内分泌科常见的一种疾病，中老年人、有家族史者以及肥胖者是多发群体，该类患者主要的临床症状为多饮、多尿、多食以及疲乏无力等等[1-2]。临床建议，针对初发2型糖尿病患者，有必要在明确诊断的基础上，采取及时有效的治疗方案[3-4]。该次选取2015年1月―2016年1月收治的92例初发2型糖尿病患者作为研究的对象，主要是对甘精胰岛素联合那格