糖尿病合并骨质疏松症相关危险因素剖析.docVIP

糖尿病合并骨质疏松症相关危险因素剖析 　　[摘要] 目的 探讨糖尿病合并骨质疏松症患者的相关危险因素。 方法 选取2015 年1～7月辽宁医学院附属第一医院内分泌科收治的糖尿病患者100例为研究对象，根据骨密度将患者分为骨质疏松症组（50例）和非骨质疏松症组（50例），通过问卷调查、实验室检查等方法收集患者性别、年龄、糖尿病病程、日照时间、运动量、糖化血红蛋白及慢性并发症等情况，进一步判断骨质疏松症可能的相关危险因素。 结果 糖尿病患者骨质疏松症的发生与患者性别、年龄、糖尿病病程、糖化血红蛋白水平、尿微量白蛋白水平呈正相关（P = 0.000、P = 0.000、P = 0.004、P = 0.017），与日照时间、运动量、体重指数呈负相关（P = 0.024、P = 0.010、P = 0.000），与糖尿病周围神经病变和大血管病变发生率无相关关系。 结论 糖尿病患者骨质疏松症的发生与女性、老龄化、血糖控制不佳、糖尿病肾病、体重指数低、日照时间和运动量少相关。 　　[关键词] 糖尿病；骨质疏松症；相关危险因素 　　[中图分类号] R587.1；R681 [文献标识码] A [文章编号] 1673-7210（2016）06（c）-0069-04 　　[Abstract] Objective To investigate the related risk factors of diabetes combined with osteoporosis. Methods One hundred cases of patients with diabetes admitted to Department of Endocrinology of the First Affiliated Hospital of Liaoning Medical University from January to July 2015 were selected as research objects. According to bone mineral density， the patients were divided into osteoporosis group （50 cases） and non-osteoporosis group （50 cases）. Through questionnaire survey and laboratory examination， the conditions of gender， age， diabetes duration， sunshine duration， amount of exercise， glycosylated hemoglobin， chronic complications and other conditions were collected， so as to further judge the related risk factors of osteoporosis. Results The occurrence of osteoporosis in patients with diabetes had positive correlations with gender， age， diabetes duration， glycosylated hemoglobin levels， urine microalbumin levels （P = 0.000， P = 0.000， P = 0.004， P = 0.017）， which had negative correlations with sunshine duration， amount of exercise， body mass index （P = 0.024， P = 0.010， P = 0.000）， which had no correlations with diabetic peripheral neuropathy and the incidence of macroangiopathy. Conclusion The occurrence of osteoporosis in patients with diabetes is correlated with female， aging， poor glycemic control， diabetic nephropathy， low body mass index， less sunshine duration and amount of exercise. 　　[Key words] Diabetes； Osteoporosis； R