莨菪类药物治疗重症手足口病微循环障碍65例剖析.docVIP

莨菪类药物治疗重症手足口病微循环障碍65例剖析 　　【摘要】 目的 分析莨菪类药物治疗重症手足口病微循环障碍的临床疗效，探讨治疗重症手足口病微循环障碍的有效方法。方法 采用回顾性分析的方法对笔者所在医院收治的重症手足口病微循环障碍的65例患儿的相关信息进行分析。结果 重症手足口病微循环障碍临床发生率高，严重影响患儿预后。及时应用莨菪类药物治疗能迅速改善微循环，缓解病情，改善预后，达到良好临床效果。结论 莨菪类药物治疗重症手足口病微循环障碍临床疗效显著，不良反应轻微，能显著提高治愈率，降低病死率。? 　　【关键词】 莨菪类药物； 重症手足口病； 微循环障碍?? 　　The analysis of henbane drugs in treatment of 65 cases of microcirculatory disturbance in severe hand-foot-mouth disease XIA De-quan, WU Cui-ping, NI Xiu-ying. Yidu Central Hospital of Weifang, Weifang 262500, China? 　　【Abstract】 Objective To analyze the clinical effects of henbane drugs in treatment of 65 cases of microcirculatory disturbance in severe hand-foot-mouth disease and discuss the effective therapy of microcirculatory disturbance in severe hand-foot-mouth disease.Methods The clinical datas of 65 cases of microcirculatory disturbance in severe hand-foot-mouth disease in the authors? hospital were retrospectively analysed.Results Microcirculatory disturbance in severe hand-foot-mouth disease affected prognosis seriously with high morbidity.The timely henbane drugs therapy could improve the microcirculation quickly, alleviate symptoms and improve prognosis,which could get good results.Conclusion The clinical effects of Henbane Drugs in treatment of microcirculatory disturbance in severe hand-foot-mouth disease is significant with mild adverse reaction.It can significantly improve the cure rate and decrease the mortality rate.? 　　【Key words】 Henbane drugs; Severe hand-foot-mouth disease; Microcirculatory disturbance? 　　doi：10.3969/j.issn.1674-4985.2012.03.073 　　?? 　　 　　手足口病（HFMD）是由多种肠道病毒引起的急性肠道传染病，临床以发热和手掌、足底、臀部及口腔等部位的斑丘疹、疱疹和溃疡为主要特征。大部分患儿预后良好，但有少数患儿可并发脑干脑炎、心肌炎、急性迟缓性麻痹、神经源性肺水肿等，个别重症者病情进展快，病死率高[1]。外周微循环障碍是重症手足口病患儿较早期病理改变，是发生神经源性肺水肿的先兆。笔者对有外周微循环障碍的重症手足口病患儿及时应用莨菪类药物治疗，取得了很好的临床效果。现将应用东莨菪碱治疗外周微循环障碍的65例重症手足口病患儿相关资料总结分析如下。? 　　1 资料与方法? 　　1.1 一般资料 65例患儿均符合重症手足口病的诊断标准[2]。其中男29例，女36例；年龄1个月～1岁42例，1～3岁23例。随机分为治疗组32例，其中男13例，女19例；年龄1个月～1岁21例，1～3岁11例。对照组33例，男16例，女17例；年龄1个月～1岁21例，1～3岁