步长脑心通胶囊合福辛普利对家兔心肌缺血再灌注损伤及血管紧张素Ⅱ,内皮素影响的研究-中西医结合;临床专业论文.docx

优秀毕业论文 精品参考文献资料 Buchang Naoxintong together Fosinopril on rabbit myocardial ischemia-reperfusion injury and endothelin, angiotensin II study on the impact of ABSTRACT Objective:To observe the angiotensin II (angiotensinII, AngII) and endothelin (Endothelins, ET) in myocardial ischemia - reperfusion injury (Ischemia-reperfusion injury IRI) Change the time to study the step size depends on shared Naoxintong Sinop Lee on myocardial ischemia - reperfusion injury in the efficacy of traditional Chinese and western medicine to explore the preventive and therapeutic effects of IRI. Methods:Radioimmunoassay Detect and IRI in normal control rabbits AngII and ET plasma levels and correlation analysis. Step one of Naoxintong and Fosinopril group (A group) step Naoxintong group (B group), Fosinopril group (C group) . Another eight normal control group (D group). Results:B, C, D plasma AngII were significantly higher than A group (p 0.05 or p 0.01); D plasma AngII higher than B, C group (p 0.01); C group than the B group of plasma AngII (p 0.05); D group ET was significantly higher than A, B (P 0.05 or P 0.05), D group ET higher than B, C group (p 0.01), C group B higher than the ET group (P 0.05); ET at A, B groups were not significantly different. AngII and ET has a positive correlation between (r = 0.43, P 0.05). Conclusion:After step Naoxintong and Fosinopril administered by the IRI model of rabbit plasma angiotensin II and endothelin levels were significantly lower than the other control groups, suggesting that the two drugs combined can play better against The role of IRI. Key words: myocardial ischemia-reperfusion; angiotensin II; endothelin 引 言 冠心病是目前世界上的高发病，有着很高的死亡率和致残率，此 外，由其所造成的心肌梗死，顽固性心绞痛，恶性的心律失常等，严 重影响了许多患者的生活质量。目前，世界各地已经广泛的在应用冠 状动脉旁路移植术，而在该手术中，需要短暂的阻断冠状动脉，恢复 血流后，由于血流再灌注可以对心肌造成损伤，并造成局部的心肌坏 死和凋亡，致使术后心功能恢复的时间延迟。多年来，随着医学技术 日新月异的发展，随着对心肌缺血--再灌注损伤发生机制研究的不断 深入，许多行之有效的西药和外科介入手术逐渐应用于临床，能够快 速的减轻患者的症状，改善患者的生活质量。与此同时，传统中医药 在心肌缺血--再灌注损伤的防治上也取得了长足的进展。大量研究显 示，中药在防治心肌缺血