大剂量地塞米松冲击治疗原发免疫性血小板减少症(ITP)疗效的回顾性分析-血液内科专业论文.docx

A retrospective analysis of the efficacy of high-dose dexamethasone impact treatment on primary immune thrombocytopenia (ITP) Abstract Objective: Through comparing the curative effect and complications between high-dose dexamethasone impact therapy and traditional glucocorticoids treatment of primary immune thrombocytopenia (ITP) ，to provide some theoretical basis for reasonable treatment options in clinical work. Methods: Retrospective method was used to analyze the clinical data of 40 cases of adult patients with immune thrombocytopenia which treated in August 2012 to December 2013 years in our hematology department of Zunyi Medical College affiliated hospital. These patients were randomly divided into 2 groups, group A (20 cases) was treated with high-dose dexamethasone impact therapy (40mg/d×4 days) and group B (20 cases) was treated with traditional glucocorticoids therapy (oral prednisone at a dose of 1mg/kg/d, slow reduction begins after relieve, 5mg per week, and then maintain a small dose therapy), compared the efficacy of two groups. Results: In the seventh day，the platelet in High-dose dexamethasone group were higher than traditional group (P 0.05); but in the fourteenth day, the difference between the two groups has no statistical significance (P 0.05). High-dose dexamethasone group compared with the traditional group, the total response rate were 90%, 85% respectively, the difference has no statistical significance (P 0.05). High-dose dexamethasone group compared with the traditional group, the incidence of complications were 10%, 25% respectively, the difference has no statistical significance (P 0.05). Conclusions: Both High-dose dexamethasone impact group and traditional glucocorticoids group have the same total response rate. Both High-dose dexamethasone impact group and traditional glucocorticoids group can cause platelets raise, but the former platelets rose more obvious the seventh day, and has no significant difference in the