改性氧化镁晶须左旋聚乳酸生物复合材料制备与性能-材料学专业论文.docxVIP

Abstract Poly L-lactic Acid (PLLA) is a typical kind of biodegradable polymer widely used in clinical application, due to the advantage of raw material renewable, synthesizing process controlled, and its excellent properities of mechanics, inherent biocompatibility and so forth. It has becomed the researching hotspot especially in bone repairing as bone-implant materials. However, there are some defects in its degradable course which severely limits its more widely application. These are performed in the obvious reduction of pH of humoral and mechanical properties caused by lactic acid generated from intermediate product in degradable process which can also accelerate PLLA degradation, and these problems lead to the fact that the variation of PLLA can not match well with the growth of the human bone. In this paper, in order to obtain biodegradable absorption materials of bone fixation to satisfy the clinical requirement, MgO whisker, which is alkaline corrosion degradation in the body fluids, is utillized for preparing the biocomposite material with PLLA as matrix, and the effect of varying MgO whisker amount was investigated to performance of PLLA degradation, mechanical properties and also biological activity. In this paper, we prepared MgO whisker by chemical method and also researched the factors affecting its morphology. Then copolymer of D,L-malicacid-low molecular weight polylactic acid, aluminate coupling agent and stearic acid were used to modify MgO whisker, respectively, aim at improving the dispersion of MgO whisker in PLLA and enhancing the interface of filler and matrix. Solution blending- pouring methond was used to prepare the composite films of modified MgO whisker/PLLA. The research was mainly focused on the influence of adding amount of MgO whisker on PLLA in aspect of mechanical properties, crystallization behavior, the degradation and cytotoxicity of PLLA. The researching results showed that: Aging 0.6mol/L MgCl2·6H2O and Na2CO3 mixed solu