肥大细胞与肠易激综合征低度炎症关系的研究进展-内科学(消化)专业论文.docxVIP

重庆医科 重庆医科大学硕士研究生学位论文 万方数据 万方数据 英汉缩略语名词对照 英文缩写 IBS 英文全称 irritable bowel syndrome 中文全称 肠易激综合征 D-IBS diarrhea-predominant IBS 腹泻型肠易激综合征 C-IBS constipation-predominant IBS 便秘型肠易激综合征 M-IBS mixed IBS 混合型肠易激综合征 U-IBS unsubtyped IBS 未定型肠易激综合征 MC mast cell 肥大细胞 5-HT PI-IBS 5-hydroxytryptamine(serotonin) post-infectious irritable bowel syndrome 5-羟色胺 感染后肠易激综合征 CD cluster of differentiation 白细胞分化抗原 IL interleukin 白细胞介素 TNF-α IFN-γ tumor necrosis factor-α interferon-γ 肿瘤坏死因子-α γ 干扰素 IL-1ra TGF-β Th RT-PCR interleukin-1 receptor antagonist transforming growth factor-beta T helper cells reverse transcription-polymerase chain 白介素-1 受体拮抗剂 转化生长因子-β 辅助性 T 细胞 HYPERLINK /view/113742.htm 逆转录- HYPERLINK /view/95003.htm 聚合酶链反应 reaction PAR-2 TJ protease-activated receptor-2 tight junction 蛋白酶活化受体-2 紧密连接 ZO zonula occludens 闭锁小带 JAM junctional adhesion molecule 连接粘附分子 EDTA ethylene diamine tetraacetic acid 乙二胺四乙酸 1 肥大细胞与肠易激综合征低度炎症关系的研究进展 摘要 肠易激综合征（irritable bowel syndrome，IBS）是临床上一种很常 见的功能性肠道疾病，尽管在该领域有大量的研究，但 IBS 的机理仍 不完全清楚。近年来，越来越多的研究表明，IBS 患者肠道虽缺乏形态 学和生化的异常，但却存在肥大细胞等免疫细胞的数量及功能异常， 导致肠道持续低度炎症，肥大细胞在 IBS 发病机理中占重要地位。本 文，我们针对肥大细胞在肠易激综合征低度炎症方面的机理作一综述。 关键词：肠易激综合征，肥大细胞，低度炎症，细胞因子，肠粘 膜上皮屏障 2 THE PATHOGENESIS OF MAST CELL IN TERMS OF LOW-GRADE INFLAMMATION IN IRRITABLE BOWEL SYNDROME ABSTRACT Irritable bowel syndrome(IBS) is a common functional intestinal disorder in clinic. Although a great deal of studies have been carried out in this area, the mechanism of IBS is not completely understood. The intestine of IBS doesn’t exhibit morphological or biochemical abnormalities. But recently, more and more studies indicate that various immune cells, for instance mast cell, are abnormal in the amount and function, which result in persistent low-grade inflammation. Mast cell plays an important role in IBS. In this article, we briefly summarize the pathogenesis of mast cell in terms of low-grade inflammation in irritable bowel syndrome. Key words: irritable bowel syndrome, mast cell, low-grade inflammation,