复方芪鹰颗粒对DPN患者胰岛素样生长因子-1影响的临床研究-中医内科学专业论文.docx

— — PAGE 1— 摘 要 复方芪鹰颗粒对 DPN 患者胰岛素样生长因子-1 影响的 临床研究 研究生：张文佳 导师：胡晓灵主任医师 摘 要 目的：观察复方芪鹰颗粒对糖尿病周围神经病变患者的疗效并探讨该方作用机 理。方法：将 77 例患者随机分为两组，在常规治疗基础上，治疗组（40 例）加服复 方芪鹰颗粒治疗，对照组加服糖脉康颗粒治疗，疗程 4 周。观察患者治疗前后综合 疗效、临床症状、空腹血糖、餐后两小时血糖、神经传导速度、胰岛素样生长因子-1 水平。结果：治疗组和对照组患者临床症状及血糖均有改善，治疗组临床综合疗效 优于对照组（P0.05）；治疗组降低空腹血糖疗效优于对照组（P0.05）；治疗组用药 后胰岛素样生长因子-1 水平升高，有统计学意义（P0.05），对照组治疗前后结果无 统计学意义。治疗组用药后神经传导速度较对照组提高，有统计学意义（P0.05）。 结论：复方芪鹰颗粒可改善糖尿病周围神经病变患者临床症状，加快感觉及运动神 经传导速度，改善糖代谢异常，并通过升高胰岛素样生长因子-1 水平，达到促进神 经再生作用，可能为该方治疗 DPN 的机理之一。 关键词：复方芪鹰颗粒；糖尿病周围神经病变；胰岛素样生长因子-1；临床研究 新疆医科大学医学硕士学位论文 Clinical Study on healing effect of DPN and influence of IGF-1 by formulation of Fu Fang Qi Ying Postgraduate：Zhang Wenjia Supervisor：Hu Xiaoling Abstract Objective：To observe the clinic curative effect of Diabetic Peripheral Neuropathy （DPN） and discuss the mechanism of action by formulation of Fu Fang Qi Ying. Method：In clinic study， 77 cases of Diabetic Peripheral Neuropathy were divided into two groups at random,treatment group (n=40) and control group (n=37).The treatment group were treated with granular formulation of Fu Fang Qi Ying,while the control group with granular formulation of Tang Mai Kang.Four weeks later,we observed the effect on the patients.Observing the symptoms and total effective ratios,making measurement of FBG,2HBG,IGF-1 in the blood and NCV before and after the treatment.Results：After four weeks of treatment,both the symptom and BG for patients of tow groups are improve.The clinic synthetic effectiveness in the treatment group is better than the control group,and the effect of treatment group to reduce FBG is better than the control group,the differences were significant (P0.05). After treatment, it was significant that the level of VEGF was raised in the treatment group, but it was nosignificant in the control group. The NCV in the treatment group was accelerated than the control group, the differences were significant (P0.05).Conclusions: The granular formulation of Fu Fang Qi Ying can obviously