梗死后出血转化中基质金属蛋白酶表达与其发病机制的实验分析.pdfVIP

Researchofmatrix Experimental metalloproteinaseexpression．．9 transformationandthe mechanism duringhemorrhage possible observe the of cerebral Abstract：Objective：To damageexperimental rats of andtlie ischemia-reperfusion mechanism．Toobservematrix． possible metalloproteinase一9 transformationandthe expression duringhemorrhage mechanism．Methods：Themodeloffocalbrain possible ischemiawas suture produced occulusionofthemiddlecerebral by锄intraluminal artery rats．1 80adultmalewistarratswere (MCA)in used．Theratswere randomly dividedintothree all groups：sham operationgroUpundergoing surgical butthe intraluminalsuture procedures occulusionofthemiddlecerebral artery, ischemia—reperfusion ischemia group，continuous group．Ischemiareperfusion hasfive todifferent group subgroups ischemiatimeof according 3h，6h，12h，