水飞蓟宾对猪脑基底动脉5－li￣氧酶活性的抑制作用-Acta.PDF

i localization andsubtypesat rc—orpostsyflap- 11Antonaceio Ⅲ 。Robson RD。Kerwin L-Ev tic sites．Prog Phys如}Sci1987：18 ：338 dence for increased vagaltone and Lfflharlce- 10Booth NH ．Nonnarcoticalialgesics．In：Boo恤 m erit of tmrorecvptor reflex activity aftel NH。McDonaldLE．eds．Veterinary #arm - xylazine (2-(2，8-dimethylphenylamino) -4一 cology w4d therapeutics．8th ed．Atnes．Iowa： H一8．8-dihydro-I，3一thiazjne) in anes恤 etized Iowa State University Press，1982 ：297—320 dogs．E “rJ pharmac0f1973．23：311 丰 木 卓 木 卓 木 中国药理学报 ActaPharmacologi∞ Sinica t989Sep；lO (5)：414-418 水飞蓟宾对猪脑基底动脉 5-li~氧酶活性的抑制作用- ● 林爱友。、芮耀诚 (第二军医大学药学院药理教研室，上海200433，中国) Inhibitory effectofsflybin on theactivity of 5-lipoxygenase ofthe porcine cerebral Imsflar artery LIN A i—You， RUIYao-Cheng ． (DepartmentoiPharmacology，Co~Mge Pharmacy，Second Mliitary Medical University．Slumghai 288438，China) AB RACT The chopped porcine cerebral waspreblockcdbyatropine l#mol／L，di— basilararteries (PCBA)were incubateel in phen五ydraminelgtmol／L and cyprohepta- the modifed Tyrode solution with calcium dine3nmol／L．ThecOntractionproducedby ionophoreealcimycin (A-23187， C 1) l0 the extract on the ileum showed the sBm p．mol／L in thepresen~eofarachidonicacid e．haracterestic as LTD．． and was blocked 30．8#mol／L and indomethacin．a cyc1o- by the specific LTsantagonist FPL 55712 oxygenaseinhibitor2．8~mol／L．Theculture 100ng／m1．Reversedpha