ModelChain-基于私有区块链网络的分布式隐私保护医疗预测模型框架.pdfVIP

ModelChain: Decentralized Privacy-Preserving Healthcare Predictive Modeling Framework on Private Blockchain Networks 1 1 1,2 Tsung-Ting Kuo, PhD, Chun-Nan Hsu, PhD, and Lucila Ohno-Machado, MD, PhD 1Health System Department of Biomedical Informatics, University of California San Diego, La Jolla, CA 2Division of Health Services Research Development, VA San Diego Healthcare System Abstract Cross-institutional healthcare predictive modeling can accelerate research and facilitate quality improvement initiatives, and thus is important for national healthcare delivery priorities. For example, a model that predicts risk of re-admission for a particular set of patients will be more generalizable if developed with data from multiple institutions. While privacy-protecting methods to build predictive models exist, most are based on a centralized architecture, which presents security and robustness vulnerabilities such as single-point-of-failure (and single-point-of-breach) and accidental or malicious modification of records. In this article, we describe a new framework, ModelChain, to adapt Blockchain technology for privacy-preserving machine learning. Each participating site contributes to model parameter estimation without revealing any patient health information (i.e., only model data, no observation-level data, are exchanged across institutions). We integrate privacy- preserving online machine learning with a private block chain network, apply transaction metadata to disseminate partial models, and design a new proof-of-information algorithm to determine the order of the online learning process. We also disc