骨髓间充质干细胞向神经细胞的分化.PDF

第25卷第1期 生命科学 Vol. 25, No. 1 2013年1月 Chinese Bulletin of Life Sciences Nov., 2013 文章编号：1004-0374(2013)01-0084-07 骨髓间充质干细胞向神经细胞的分化 安秀峰，黄汉昌，姜招峰* (北京联合大学功能食品科学技术研究院，生物活性物质与功能食品北京市重点实验室，北京100191) 摘　要：近年来，骨髓间充质干细胞逐渐成为神经科学领域的研究热点，广泛用于治疗神经退行性疾病， 其原因是；骨髓间充质干细胞可在诱导物存在下定向分化为有功能的神经元细胞，并能成功表达神经标志 蛋白。结合近几年的研究进展，主要从骨髓间充质干细胞的临床试验和应用 ；激光辐射、氧气含量和神经 细胞对骨髓间充质干细胞分化为神经细胞的影响；microRNA 、Notch 信号通路和Wnt 信号通路对骨髓间充 质干细胞分化为神经细胞的调节作用等三方面进行阐述。 关键词：骨髓间充质干细胞；神经细胞；影响因素 中图分类号：Q813 ；Q189 ；R392　　 文献标志码 ：A Bone marrow mesenchymal stem cells differentiation into nerve cells AN Xiu-Feng, HUANG Han-Chang, JIANG Zhao-Feng* (Beijing Key Laboratory of Bioactive Substances and Functional Foods, Research Institute for Science and Technology of Functional Food, Beijing Union University, Beijing 100191, China) Abstract: For the past few years, bone marrow mesenchymal stem cells have gradually become a research focus in the field of neuroscience, and have been widely used in the treatment of neurodegenerative diseases. It is just because that it can differentiate into functional neuron and express neural marker proteins successfully when inducer exists. Combined with the recent research progress, this paper will introduce the bone marrow mesenchymal stem cells from the following three aspects: firstly, the clinical trial and application of bone marrow mesenchymal stem cells; secondly, the effects of laser radiation, oxygen content and the nerve cells on the process of bone marrow mesenchymal stem cells differentiate into nerve cells; thirdly, microRNA, Notch signal pathway and Wnt signal pathway regulate the process of bone marrow mesenchymal stem cells differentiating into nerve cells.