拉莫三嗪治疗脑损伤后脑水肿的实验研究.doc

拉莫三嗪治疗脑损伤后脑水肿的实验研究 Lamotrigine is an experimental study of cerebral edema after brain injury Update date: 2010-09-08 cheng yuan Chen complex, zhang xiaoping 【 abstract 】 objective to by defense rats model, to observe the bra in injury after the excitatory amino acid glutamic acid and lamotrigine treatment effect of acute brain edema, and to explore its action mechanism. Methods using dry-wet weight method, and amino acid analysis and micro dialysis technology different areas after brain injury, not at the same time in the water content of brain tissue and the concentration of glutamate? Results (1) the amount of water in the brain tissue of the brain injury group was significantly higher than that in the control group. (2) brain edema and extracellular glutamate in the lesion of the brain lesion were self-expanding; (3) the amount of water in the bra in tissue of lamotrigine and the concentration of glutamate was significantly lower than that of the non-treatment group? Conclusion lamotriazine plays a therapeutic role in cerebral edema by inhibiting the release of glutamate from nerve cells? 【keywords 】 the cerebral edema of cerebral edema of cerebral edema, lamotriazine Effect of Lamotrigine on the Following Traumatic Brain Injury in Rats CHENG Yuan, CHEN fu-ren, WU Yong, et al Dept. Of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400042 [Abstract] Aim To investigate the effect of lamotrigine (LTG) on cerebral edema following traumatic brain injury, and to discuss the mechanism? Methods This study was done on the experimental animal models (rats) with impacted brain injury. The change of water content in brain was measured with udrying-wetv method, and the change of glutamate was measured with microdialysis technique and amino acids automaticanalyzes. Results (1) The water content and glutamate in the injured brain were significantly greater than those in the control group?(2) In the injured brain, the contents of water and glu