金属铱配合物纳米粒子的合成及其磷光成像与光动力学治疗中的应用-无机化学专业论文.docxVIP

优秀毕业论文 精品参考文献资料 Shanghai Shanghai Normal University Master of Philosophy Abstract Due to excellent photo—physical properties of iridium complexes(1arge Stocks shifts，tunable UV-vis absorption spectra and fluorescence spectra by adjusting ligand， high quantum efficiency and long phosphorescence lifetime)，iridium complexes acted as bio—imaging probes and cancer therapeuti c agents have drawn more and more widely attention by researchers around the world．In this thesis，we have already designed and synthesized a serial of iridium complexes，and studied their application in bio-imaging and photodynamic therapy．This work was divided into two parts： 1．Synthesis and metal iridium complexes in solution photodynamic therapy application We designed and synthesized three different ligands iridium complexes，and determined their structure by 1H NMR．13C NMR and MODI．TOF．We use some professional equipments to character the photophysical properties of iridium complexes，such as UV-vis，phosphorescent spectra and phosphorescent lifetime．As we all know,DMA as a standard reagent for detecting singlet oxygen．We used it to detect the production ability of singlet oxygen under400 am visible light．The results tells US that NAN ligands have a great effect on the UV-vis absorption and emission properties of iridium complexes，especially in photodynamic effect property． 2．Synthesis of benzyl alcohol iridium complex nanoparticles and photodynamic effect under visible light irradiation We found that iridium complexes have good photodynamic effect in solution． While it has some solubility in aqueous solution，but that still cannot meet the requirements of biological applications．In order to solve the poorly water-soluble iridium complex having this common different problem，we have designed and successfully developed a new method which it is different from the traditional use of complex CROSS—linking or doping to form nanoparticles．The new method uses alcoholic hydroxyl of benzyl alcohol iridium co